Journal article
Improved osseointeraction of calcium phosphate-coated external fixation pins: Studies in calves
Acta orthopaedica, Vol.68(6), pp.571-576
1997
Handle:
https://hdl.handle.net/2376/100925
PMID: 9462359
Abstract
We investigated osseointeraction of solution-precipitated calcium phosphate (SPCP)-coated transfix-ation pins used in external skeletal fixation of a calf stable fracture model. One group (SPCP) received centrally-threaded transfixation pins which had SPCP coating; the other group (control) received identical, but not coated, pins. Radiographs were obtained 1 and 40 days after surgery and examined for evidence of osteolysis. Bone phase 99rnTc-MDP studies were performed 6 and 28 days after surgery. Calves were killed 40 days after surgery and mechanical tests performed. Dual-energy x-ray absorptiometry (DEXA) and histomorphometric analyses were done. A smaller proportion of SPCP pins (5/24) had evidence of discharge during the study compared with control pins (21/24). A smaller proportion of SPCP pins (4%) had radiographic evidence of osteolysis compared with control pins (42%). Uptake of 99mTc-MDP was similar for SPCP and control calves. Uptake was significantly greater in bone segments showing radiographic evidence of osteolysis than in bone segments not having osteolysis. Yield stress (MPa) for axial displacement was similar in the treatment groups. Bone mineral density was less in SPCP pins. Affinity index and interface histologic score were greater and osteoclastic index less in SPCP calves. Coating of transfixation pins with solution-precipitated calcium phosphate improved the osseointeraction of pin and bone during this 40-day study.
Metrics
13 Record Views
Details
- Title
- Improved osseointeraction of calcium phosphate-coated external fixation pins: Studies in calves
- Creators
- David E Anderson - 1Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KansasGuy St-Jean - 1Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KansasDaniel C Richardson - 2Mark Morris Institute, Topeka, KansasRichard M De Bowes - 1Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KansasJames K Roush - 1Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KansasStephen R Lowry - 2Mark Morris Institute, Topeka, KansasPhillip W Toll - 2Mark Morris Institute, Topeka, KansasHarold M Aberman - 3Howmedica Inc., Pfizer Hospital Products Group, Rutherford, NJDavid C Van Sickle - 4Department of Basic Medical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN, USAJames J Hoskinson - 1Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas
- Publication Details
- Acta orthopaedica, Vol.68(6), pp.571-576
- Publisher
- Informa UK Ltd
- Identifiers
- 99900546677501842
- Language
- English
- Resource Type
- Journal article