Journal article
In Vitro Study of Receptor-Mediated Silica Nanoparticles Delivery across Blood-Brain Barrier
ACS applied materials & interfaces, Vol.9(24), pp.20410-20416
06/21/2017
PMID: 28541655
Abstract
A brain drug delivery system has been demonstrated by attaching lactoferrin (Lf) on the silica nanoparticles (Si NPs). The nanoparticle surface was modified with polyethylene glycol to reduce protein adsorption. The transport efficiency of Lf attached Si NPs was studied using an in vitro blood-brain barrier (BBB) model consisting of three distinct types of cells: endocytes, pericytes, and astrocytes. Transfer of NPs from the apical side to the basolateral side is observed. The results indicated that Lf attached Si NPs demonstrated enhanced transport efficiency across the BBB with size-dependence compared to bare Si NPs. The maximum transport efficiency of lactoferrin conjugated silica nanoparticle was observed for 25 nm diameter particles. This receptor-mediated transcytosis of Si NPs across the cerebral endothelial cells can be employed to deliver drugs and imaging probes to the brain.
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Details
- Title
- In Vitro Study of Receptor-Mediated Silica Nanoparticles Delivery across Blood-Brain Barrier
- Creators
- Yang Song - Washington State UniversityDan Du - Washington State UniversityLei Li - Washington State UniversityJun Xu - Washington State UniversityPrashanta Dutta - Washington State UniversityYuehe Lin - Washington State University
- Publication Details
- ACS applied materials & interfaces, Vol.9(24), pp.20410-20416
- Academic Unit
- School of Mechanical and Materials Engineering
- Grant note
- R01 GM122081 / NIGMS NIH HHS
- Identifiers
- 99901227842001842
- Language
- English
- Resource Type
- Journal article