Journal article
In Vitro Trafficking and Efficacy of Core-Shell Nanostructures for Treating Intracellular Salmonella Infections
Antimicrobial agents and chemotherapy, Vol.53(9), pp.3985-3988
09/2009
Handle:
https://hdl.handle.net/2376/115922
PMCID: PMC2737852
PMID: 19596872
Abstract
Nanostructures encapsulating gentamicin and having either amphiphilic (N1) or hydrophilic (N2) surfaces were designed. Flow cytometry and confocal microscopy studies demonstrated a higher rate of uptake for amphiphilic surfaces. A majority of N1 were localized in the cytoplasm, whereas N2 colocalized with the endosomes/lysosomes. Colocalization was not observed between nanostructures and intracellular
Salmonella
bacteria. However, significant in vitro reductions in bacterial counts (0.44 log
10
) were observed after incubation with N1, suggesting that the surface property of the nanostructure influences intracellular bacterial clearance.
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Details
- Title
- In Vitro Trafficking and Efficacy of Core-Shell Nanostructures for Treating Intracellular Salmonella Infections
- Creators
- A Ranjan - Department of Large Animal Clinical SciencesN Pothayee - Department of Large Animal Clinical SciencesM. N Seleem - Department of Large Animal Clinical SciencesN Sriranganathan - Department of Large Animal Clinical SciencesR Kasimanickam - Department of Large Animal Clinical SciencesM Makris - Department of Large Animal Clinical SciencesJ. S Riffle - Department of Large Animal Clinical Sciences
- Publication Details
- Antimicrobial agents and chemotherapy, Vol.53(9), pp.3985-3988
- Academic Unit
- Veterinary Clinical Sciences, Department of
- Publisher
- American Society for Microbiology (ASM)
- Identifiers
- 99900547884401842
- Language
- English
- Resource Type
- Journal article