In Vivo Cocaine Experience Generates Silent Synapses

Yanhua H Huang; Ying Lin; Ping Mu; Brian R Lee; Travis E Brown; Gary Wayman; Helene Marie; Wenhua Liu; Zhen Yan; Barbara A Sorg; Oliver M Schlüter; R. Suzanne Zukin; Yan Dong

doi:10.1016/j.neuron.2009.06.007

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In Vivo Cocaine Experience Generates Silent Synapses

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In Vivo Cocaine Experience Generates Silent Synapses

Yanhua H Huang, Ying Lin, Ping Mu, Brian R Lee, Travis E Brown, Gary Wayman, Helene Marie, Wenhua Liu, Zhen Yan, Barbara A Sorg, …

Neuron (Cambridge, Mass.), Vol.63(1), pp.40-47

2009

DOI: https://doi.org/10.1016/j.neuron.2009.06.007

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https://hdl.handle.net/2376/104138

PMCID: PMC2721479

PMID: 19607791

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Abstract

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Studies over the past decade have enunciated silent synapses as prominent cellular substrates for synaptic plasticity in the developing brain. However, little is known about whether silent synapses can be generated postdevelopmentally. Here, we demonstrate that highly salient in vivo experience, such as exposure to cocaine, generates silent synapses in the nucleus accumbens (NAc) shell, a key brain region mediating addiction-related learning and memory. Furthermore, this cocaine-induced generation of silent synapses is mediated by membrane insertions of new, NR2B-containing N-methyl- D-aspartic acid receptors (NMDARs). These results provide evidence that silent synapses can be generated de novo by in vivo experience and thus may act as highly efficient neural substrates for the subsequent experience-dependent synaptic plasticity underlying extremely long-lasting memory.

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Title: In Vivo Cocaine Experience Generates Silent Synapses
Creators: Yanhua H Huang - Program in Neuroscience, Washington State University, Pullman, WA 99164-6520, USA
Ying Lin - Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Ping Mu - Program in Neuroscience, Washington State University, Pullman, WA 99164-6520, USA
Brian R Lee - Program in Neuroscience, Washington State University, Pullman, WA 99164-6520, USA
Travis E Brown - Program in Neuroscience, Washington State University, Pullman, WA 99164-6520, USA
Gary Wayman - Program in Neuroscience, Washington State University, Pullman, WA 99164-6520, USA
Helene Marie - European Brain Research Institute, Via del Fosso di Fiorano, 64 – 00143, Rome, Italy
Wenhua Liu - Department of Physiology, State University of New York at Buffalo, Buffalo, NY 14214, USA
Zhen Yan - Department of Physiology, State University of New York at Buffalo, Buffalo, NY 14214, USA
Barbara A Sorg - Program in Neuroscience, Washington State University, Pullman, WA 99164-6520, USA
Oliver M Schlüter - Department of Molecular Neurobiology, European Neuroscience Institute, Grisebachstrasse 5, 37077 Göttingen, Germany
R. Suzanne Zukin - Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Yan Dong - Program in Neuroscience, Washington State University, Pullman, WA 99164-6520, USA
Publication Details: Neuron (Cambridge, Mass.), Vol.63(1), pp.40-47
Academic Unit: Integrative Physiology and Neuroscience, Department of
Publisher: Elsevier Inc
Identifiers: 99900546988701842
Language: English
Resource Type: Journal article