In Vivo Response of Laser Processed Porous Titanium Implants for Load-Bearing Implants

Amit Bandyopadhyay; Anish Shivaram; Solaiman Tarafder; Himanshu Sahasrabudhe; Dishary Banerjee; Susmita Bose

doi:10.1007/s10439-016-1673-8

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In Vivo Response of Laser Processed Porous Titanium Implants for Load-Bearing Implants

Journal article

Open access

Peer reviewed

In Vivo Response of Laser Processed Porous Titanium Implants for Load-Bearing Implants

Amit Bandyopadhyay, Anish Shivaram, Solaiman Tarafder, Himanshu Sahasrabudhe, Dishary Banerjee and Susmita Bose

Annals of biomedical engineering, Vol.45(1), pp.249-260

01/2017

DOI: https://doi.org/10.1007/s10439-016-1673-8

Handle:

https://hdl.handle.net/2376/108905

PMCID: PMC5159332

PMID: 27307009

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https://doi.org/10.1007/s10439-016-1673-8View

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Abstract

Titanium - pharmacology

Implants, Experimental

Titanium - chemistry

Rats

Male

Materials Testing

Rats, Sprague-Dawley

X-Ray Microtomography

Nanotubes - chemistry

Animals

Lasers

Weight-Bearing

Porosity

Applications of porous metallic implants to enhance osseointegration of load-bearing implants are increasing. In this work, porous titanium implants, with 25 vol.% porosity, were manufactured using Laser Engineered Net Shaping (LENS™) to measure the influence of porosity towards bone tissue integration in vivo. Surfaces of the LENS™ processed porous Ti implants were further modified with TiO nanotubes to improve cytocompatibility of these implants. We hypothesized that interconnected porosity created via additive manufacturing will enhance bone tissue integration in vivo. To test our hypothesis, in vivo experiments using a distal femur model of male Sprague-Dawley rats were performed for a period of 4 and 10 weeks. In vivo samples were characterized via micro-computed tomography (CT), histological imaging, scanning electron microscopy, and mechanical push-out tests. Our results indicate that porosity played an important role to establish early stage osseointegration forming strong interfacial bonding between the porous implants and the surrounding tissue, with or without surface modification, compared to dense Ti implants used as a control.

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Title: In Vivo Response of Laser Processed Porous Titanium Implants for Load-Bearing Implants
Creators: Amit Bandyopadhyay - W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, 99164-2920, USA. amitband@wsu.edu
Anish Shivaram - W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, 99164-2920, USA
Solaiman Tarafder - W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, 99164-2920, USA
Himanshu Sahasrabudhe - W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, 99164-2920, USA
Dishary Banerjee - W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, 99164-2920, USA
Susmita Bose - W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, 99164-2920, USA
Publication Details: Annals of biomedical engineering, Vol.45(1), pp.249-260
Academic Unit: Mechanical and Materials Engineering, School of
Publisher: United States
Grant note: R01 AR066361 / NIAMS NIH HHS R01 AR067306 / NIAMS NIH HHS
Identifiers: 99900547292001842
Language: English
Resource Type: Journal article