Journal article
In vitro activity of ponazuril against Theileria equi
Veterinary parasitology, Vol.185(2-4), pp.282-285
04/30/2012
Handle:
https://hdl.handle.net/2376/104327
PMID: 22130334
Abstract
The equid hemoprotozoan parasite Theileria equi is endemic in most regions worldwide. Infection of horses is a cause of significant economic loss due to costs associated with disease and restriction of trade with non-endemic nations. The ability of certain drugs such as imidocarb dipropionate to eliminate persistent T. equi infection and transmission risk is controversial. The anti-protozoal agent ponazuril has been used successfully to treat equine Sarcosystis neurona and Toxoplasma gondii. The hypothesis that ponazuril inhibits replication of T. equi in vitro was tested. T. equi infected equine erythrocyte cultures were treated with ponazuril at multiple concentrations. Cessation of parasite replication was observed over a 5-day period and the degree of inhibition was variable between drug concentrations. Ponazuril inhibited T. equi in erythrocyte culture at all concentrations tested but parasite elimination required at least 500μg/mL. The high dose of ponazuril required for in vitro inhibition likely limits its ability to control or clear T. equi infection in vivo, however additional research to evaluate related drugs is warranted.
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Details
- Title
- In vitro activity of ponazuril against Theileria equi
- Creators
- L. Nicki Wise - Department of Veterinary Microbiology and Pathology, ABDF 3005 Washington State University, Pullman, WA 99164-7040, United StatesMassaro W Ueti - Animal Disease Research Unit, U.S. Department of Agriculture, Agricultural Research Service, PO Box 646630, Pullman, WA 99164-6630, United StatesLowell S Kappmeyer - Animal Disease Research Unit, U.S. Department of Agriculture, Agricultural Research Service, PO Box 646630, Pullman, WA 99164-6630, United StatesMelissa T Hines - College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996-4546, United StatesStephen N White - Department of Veterinary Microbiology and Pathology, ABDF 3005 Washington State University, Pullman, WA 99164-7040, United StatesWendell Davis - Bayer HealthCare LLC, Animal Health, PO Box 390, Shawnee, KS 66216, United StatesDonald P Knowles - Department of Veterinary Microbiology and Pathology, ABDF 3005 Washington State University, Pullman, WA 99164-7040, United States
- Publication Details
- Veterinary parasitology, Vol.185(2-4), pp.282-285
- Academic Unit
- Veterinary Microbiology and Pathology, Department of; Paul G. Allen School for Global Animal Health
- Publisher
- Elsevier B.V
- Identifiers
- 99900546642001842
- Language
- English
- Resource Type
- Journal article