Inactivation of the paraventricular thalamus abolishes the expression of cocaine conditioned place preference in rats

Jenny R Browning; Heiko T Jansen; Barbara A Sorg

doi:10.1016/j.drugalcdep.2013.09.021

Back

Inactivation of the paraventricular thalamus abolishes the expression of cocaine conditioned place preference in rats

Journal article

Open access

Peer reviewed

Inactivation of the paraventricular thalamus abolishes the expression of cocaine conditioned place preference in rats

Jenny R Browning, Heiko T Jansen and Barbara A Sorg

Drug and alcohol dependence, Vol.134(1), pp.387-390

01/01/2014

DOI: https://doi.org/10.1016/j.drugalcdep.2013.09.021

Handle:

https://hdl.handle.net/2376/108372

PMCID: PMC3910376

PMID: 24139547

Files and links (1)

url

https://doi.org/10.1016/j.drugalcdep.2013.09.021View

Published (Version of record) Open

Abstract

Cocaine - administration & dosage

Animals

Conditioning, Operant - drug effects

GABA Agonists - administration & dosage

Microinjections - methods

Conditioning, Operant - physiology

Rats

Male

Rats, Sprague-Dawley

Midline Thalamic Nuclei - drug effects

Midline Thalamic Nuclei - metabolism

The paraventricular thalamus (PVT) is rapidly becoming recognized as part of the addiction circuitry. In addition to its strong anatomical connection to most of the brain regions underlying addiction, such as the nucleus accumbens, prefrontal cortex, amygdala, and hippocampus, the PVT has recently been shown to contribute to cocaine sensitization and reinstatement. In the present study, we examined the role of the PVT in the expression of cocaine conditioned place preference (CPP). We tested the impact of PVT inactivation by baclofen/muscimol (bac-mus) microinjection on the expression of cocaine-induced CPP in rats. Rats were implanted with guide cannulae into the PVT. Bac-mus (GABAB-GABAA agonists) or saline was injected into the PVT prior to CPP testing. Inactivation of the PVT by bac-mus prevented the expression of CPP, while placements outside the PVT did not affect CPP. Intra-PVT injections of bac-mus did not affect locomotor activity during the session. In the present study, we contribute to the growing body of research supporting a role for the PVT in addiction by demonstrating that the PVT is necessary for the expression of cocaine CPP.

Metrics

7 Record Views

Details

Title: Inactivation of the paraventricular thalamus abolishes the expression of cocaine conditioned place preference in rats
Creators: Jenny R Browning - University of Maryland, Department of Pharmacology, 655 W. Baltimore Street, Baltimore, MD 21201, USA; Washington State University, Department of Integrative Physiology and Neuroscience, 205 VBR Building, Pullman, WA 99164-7620, USA. Electronic address: jenny.browning@gmail.com
Heiko T Jansen - Washington State University, Department of Integrative Physiology and Neuroscience, 205 VBR Building, Pullman, WA 99164-7620, USA
Barbara A Sorg - Washington State University Vancouver, Department of Integrative Physiology and Neuroscience, 14204 NE Salmon Creek Avenue VCLS 208F, Vancouver, WA 98686-9600, USA
Publication Details: Drug and alcohol dependence, Vol.134(1), pp.387-390
Academic Unit: Integrative Physiology and Neuroscience, Department of
Publisher: Ireland
Grant note: R01 DA023202 / NIDA NIH HHS DA023202 / NIDA NIH HHS
Identifiers: 99900547504201842
Language: English
Resource Type: Journal article