Journal article
Increase in matrix metalloproteinase-9 levels in the rat medial prefrontal cortex after cocaine reinstatement of conditioned place preference
Synapse (New York, N.Y.), Vol.62(12), pp.886-889
12/2008
Handle:
https://hdl.handle.net/2376/117496
PMID: 18792988
Abstract
Recently we have shown that inhibition of matrix metalloproteinase (MMP) activity suppresses the reinstatement of cocaine-primed conditioned place preference (CPP) in rats. Here we explored whether cocaine-primed reinstatement was associated with increased activity of the gelatinases, MMP-2 or MMP-9, in the medial prefrontal cortex (mPFC) or dorsal hippocampus. Male Sprague-Dawley rats underwent training for cocaine-CPP followed by extinction sessions and either saline- or cocaine-priming injections. Cocaine-induced reinstatement produced significant increases in mPFC MMP-9 activity at 1, 3 and 24 hr after injection compared with saline controls. No changes in MMP-9 occurred in the hippocampus or in MMP-2 activity in either brain region. Also, no changes in mPFC MMP-9 activity were observed 1 hr after reinstatement in animals given no extinction sessions but equivalent time off in the home cage. Finally, MMP-3 protein levels were not different in either brain region at any of the three time points assessed. These results suggest that an elevation in MMP-9 activity in the mPFC may contribute to synaptic remodeling important for the reactivation of a cocaine memory, or alternatively, for the modification of a competing extinction memory during reinstatement.
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Details
- Title
- Increase in matrix metalloproteinase-9 levels in the rat medial prefrontal cortex after cocaine reinstatement of conditioned place preference
- Creators
- Travis E Brown - Department of Veterinary and Comparative Anatomy, Physiology and Pharmacology, Washington State University, Pullman, Washington 99164, USAMelissa R ForquerJoseph W HardingJohn W WrightBarbara A Sorg
- Publication Details
- Synapse (New York, N.Y.), Vol.62(12), pp.886-889
- Academic Unit
- Psychology, Department of; Integrative Physiology and Neuroscience, Department of
- Publisher
- United States
- Identifiers
- 99900548073601842
- Language
- English
- Resource Type
- Journal article