Journal article
Increased alcohol drinking in isolate-housed alcohol-preferring rats
Behavioral neuroscience, Vol.121(1), pp.111-119
02/2007
Handle:
https://hdl.handle.net/2376/114530
PMID: 17324055
Abstract
Alcoholism is a complex disorder influenced by interactions between genetic and environmental risk factors. This study examined the influence of isolate housing on ethanol intake in alcohol-preferring (P) and non-alcohol-preferring (NP) rats. Rats were isolate-housed or pair-housed for 8 weeks when between 45 and 96 days old. Ethanol drinking was assessed using a 24-hr preference test (10% ethanol vs. water) and 20-min limited access tests. A behavioral test battery was used to assess anxiety-like, depressive-like, acoustic startle, and motor behavior. Isolate housing increased home cage drinking in both lines and increased limited access drinking selectively in P rats. Isolation also reduced swim test immobility and prepulse inhibition in P rats and increased locomotor stereotypies in NP rats. Taken together, these data demonstrate that LinexEnvironment interactions influence the effects of isolation. Furthermore, isolation selectively increased ethanol intake in high drinking P rats. This effect was not correlated with changes in other behaviors. Selective enhancement of limited access ethanol drinking in P rats may represent a model whereby genetic liability to excessive drinking is enhanced by specific environmental exposures.
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Details
- Title
- Increased alcohol drinking in isolate-housed alcohol-preferring rats
- Creators
- Cindy L Ehlers - Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA. cindye@scripps.eduBrendan M WalkerJerry P PianJennifer L RothCraig J Slawecki
- Publication Details
- Behavioral neuroscience, Vol.121(1), pp.111-119
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- United States
- Grant note
- R01 AA06059 / NIAAA NIH HHS R01 AA014339 / NIAAA NIH HHS
- Identifiers
- 99900547504601842
- Language
- English
- Resource Type
- Journal article