Journal article
Increased apomorphine-induced hypothermia precedes development of hypertension in SHRs
Brain research bulletin, Vol.27(6), pp.857-859
1991
Handle:
https://hdl.handle.net/2376/107156
PMID: 1786566
Abstract
Apomorphine produced a greater hypothermic response in spontaneously hypertensive rats (SHRs) than in normotensive Wistar-Kyoto rats (WKYs). Experiments were conducted in SHRs and WKYs of three age groups to determine whether the increased hypothermie responsiveness to apomorphine occurs prior to the development of hypertension. The mean systolic blood pressures (SBPs) of SHRs and WKYs were comparable at 4–6 weeks of age. The mean SBP of SHRs were significantly greater than that of WKYs at both 8–10 and 12–15 weeks of age. Yet SHRs responded to apomorphine with significantly greater hypothermia than WKYs at all three ages. These findings indicate that the hyperresponsiveness of SHRs to apomorphine-induced hypothermia precedes the development of hypertension. This sequence of events is consistent with the hypothesis that central DA systems play a role in development of hypertension in SHRs.
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Details
- Title
- Increased apomorphine-induced hypothermia precedes development of hypertension in SHRs
- Creators
- Raymond M Quock - Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, Rockford, IL 61107 USALinda K Vaughn - Department of Basic Sciences, Marquette University School of Dentistry, Milwaukee, WI 53233 USA
- Publication Details
- Brain research bulletin, Vol.27(6), pp.857-859
- Academic Unit
- Psychology, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900547273001842
- Language
- English
- Resource Type
- Journal article