Journal article
Increased risk of lung cancer in individuals with a family history of the disease: A pooled analysis from the International Lung Cancer Consortium
European journal of cancer (1990), Vol.48(13), pp.1957-1968
09/2012
Handle:
https://hdl.handle.net/2376/106921
PMCID: PMC3445438
PMID: 22436981
Abstract
Familial aggregation of lung cancer exists after accounting for cigarette smoking. However, the extent to which family history affects risk by smoking status, histology, relative type and ethnicity is not well described. This pooled analysis included 24 case-control studies in the International Lung Cancer Consortium. Each study collected age of onset/interview, gender, race/ethnicity, cigarette smoking, histology and first-degree family history of lung cancer. Data from 24,380 lung cancer cases and 23,305 healthy controls were analysed. Unconditional logistic regression models and generalised estimating equations were used to estimate odds ratios and 95% confidence intervals.
Individuals with a first-degree relative with lung cancer had a 1.51-fold increase in the risk of lung cancer, after adjustment for smoking and other potential confounders (95% CI: 1.39, 1.63). The association was strongest for those with a family history in a sibling, after adjustment (odds ratios (OR)=1.82, 95% CI: 1.62, 2.05). No modifying effect by histologic type was found. Never smokers showed a lower association with positive familial history of lung cancer (OR=1.25, 95% CI: 1.03, 1.52), slightly stronger for those with an affected sibling (OR=1.44, 95% CI: 1.07, 1.93), after adjustment.
The occurrence of lung cancer among never smokers and similar magnitudes of the effect of family history on lung cancer risk across histological types suggests familial aggregation of lung cancer is independent of those risks associated with cigarette smoking. While the role of genetic variation in the aetiology of lung cancer remains to be fully characterised, family history assessment is immediately available and those with a positive history represent a higher risk group.
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- Title
- Increased risk of lung cancer in individuals with a family history of the disease: A pooled analysis from the International Lung Cancer Consortium
- Creators
- Michele L Coté - Wayne State University School of Medicine and the Karmanos Cancer Institute, Michigan, USAMei Liu - M.D. Anderson Cancer Center, Department of Epidemiology, Texas, USAStefano Bonassi - Clinical and Molecular Epidemiology IRCCS San Raffaele Pisana, ItalyMonica Neri - Clinical and Molecular Epidemiology IRCCS San Raffaele Pisana, ItalyAnn G Schwartz - Wayne State University School of Medicine and the Karmanos Cancer Institute, Michigan, USADavid C Christiani - Harvard University School of Public Health, Massachusetts, USAMargaret R Spitz - M.D. Anderson Cancer Center, Department of Epidemiology, Texas, USAJoshua E Muscat - Penn State University College of Medicine Division of Public Health Sciences, Pennsylvania, USAGad Rennert - CHS National Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and Bruce Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, IsraelKatja K Aben - Comprehensive Cancer Center The Netherlands, Nijmegen, The NetherlandsAngeline S Andrew - Norris Cotton Cancer Center, Department of Community & Family Medicine, Dartmouth Medical School, Lebanon, NH, USAVladimir Bencko - Institute of Hygiene and Epidemiology, Charles University, Prague, Czech RepublicHeike Bickeböller - University of Göttingen, Medical School, Department of Genetic Epidemiology, GermanyPaolo Boffetta - Mount Sinai School of Medicine, New York, USAPaul Brennan - International Agency for Research on Cancer (IARC), Lyon, FranceHermann Brenner - German Cancer Research Center, Division of Clinical Epidemiology and Aging Research, GermanyEric J Duell - Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, SpainEleonora Fabianova - Department of Occupational Health, Specialized State Health Institute, SlovakiaJohn K Field - The University of Liverpool Cancer Research Centre Roy Castle Lung Cancer Research Programme, UKLenka Foretova - Masaryk Memorial Cancer Institute, Czech RepublicSøren Friis - Danish Cancer Society, Institute of Cancer Epidemiology, DenmarkCurtis C Harris - National Cancer Institute, Molecular Genetics and Carcinogenesis Section, Maryland, USAIvana Holcatova - Institute of Hygiene and Epidemiology, Charles University, Prague, Czech RepublicYun-Chul Hong - Seoul National University, South KoreaDolores Isla - University of Zaragoza, Division of Medical Oncology, SpainVladimir Janout - Department of Preventive Medicine, Palacky University of Medicine, Czech RepublicLambertus A Kiemeney - Department of Epidemiology, Biostatistics and HTA and Department of Urology, Radboud University, Nijmegen Medical Centre, The NetherlandsChikako Kiyohara - Kyushu University Department of Basic Medicine, JapanQing Lan - National Cancer Institute, Division of Cancer Epidemiology and Genetics, USAPhilip Lazarus - Penn State University, Penn State Cancer Institute, Pennsylvania, USAJolanta Lissowska - Department of Cancer Epidemiology and Prevention, Cancer Center and Maria Sklodowska-Curie Institute of Oncology, Warsaw, PolandLoic Le Marchand - University of Hawaii Cancer Center, Hawaii, USADana Mates - Occupational Health Department, Institute of Public Health, Bucharest, RomaniaKeitaro Matsuo - Aichi Cancer Center Research Institute, JapanJose I Mayordomo - University of Zaragoza, Division of Medical Oncology, SpainJohn R McLaughlin - Samuel Lunenfeld Research Institute of Mount Sinai Hospital, Ontario, CanadaHal Morgenstern - University of Michigan School of Public Health, Ann Arbor, MI, USAHeiko Müeller - German Cancer Research Center, Division of Clinical Epidemiology and Aging Research, GermanyIrene Orlow - Memorial Sloan-Kettering Cancer, New York, USABernard J Park - Hackensack University Medical Center, New Jersey, USAMila Pinchev - CHS National Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and Bruce Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, IsraelOlaide Y Raji - The University of Liverpool Cancer Research Centre Roy Castle Lung Cancer Research Programme, UKHedy S Rennert - CHS National Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and Bruce Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, IsraelPeter Rudnai - National Institute of Environmental Health, Fodor Jozsef national Center for Public Health, Budapest, HungaryAdeline Seow - National University of Singapore, Yong Loo Lin School of Medicine, SingaporeIsabelle Stucker - INSERM U170, Department of Environmental Epidemiology, FranceNeonila Szeszenia-Dabrowska - The Nofer Institute of Occupational Medicine, PolandM Dawn Teare - University of Sheffield, Sheffield, UKAnne Tjønnelan - Danish Cancer Society, Institute of Cancer Epidemiology, DenmarkDonatella Ugolini - Dipartimento di Oncologia, Biolgia e Genetica, University of Genoa and Unit of Epidemiology and Biostatistics and Clinical Trials, National Cancer Research Institute, ItalyHenricus F.M van der Heijden - Department of Epidemiology, Biostatistics and HTA and Department of Urology, Radboud University, Nijmegen Medical Centre, The NetherlandsErich Wichmann - German Research Center for Environmental Health, Institute of Epidemiology, Helmholtz Center, Munich, GermanyJohn K Wiencke - University of California, San Francisco, Department of Epidemiology and Biostatistics, California, USAPenella J Woll - INSERM U170, Department of Environmental Epidemiology, FrancePing Yang - Mayo Clinic, Division of Epidemiology, Minnesota, USADavid Zaridze - Institute of Carcinogenesis, N.N.Blokhin Cancer Research Centre, Moscow, RussiaZuo-Feng Zhang - University of California, Los Angeles, School of Public Health Department of Epidemiology, California, USACarol J Etzel - M.D. Anderson Cancer Center, Department of Epidemiology, Texas, USARayjean J Hung - Samuel Lunenfeld Research Institute of Mount Sinai Hospital, Ontario, Canada
- Publication Details
- European journal of cancer (1990), Vol.48(13), pp.1957-1968
- Academic Unit
- Pharmaceutical Sciences, Department of
- Publisher
- Elsevier Ltd
- Identifiers
- 99900546740401842
- Language
- English
- Resource Type
- Journal article