Journal article
Independence of Anaplasma marginale Strains with High and Low Transmission Efficiencies in the Tick Vector following Simultaneous Acquisition by Feeding on a Superinfected Mammalian Reservoir Host
Infection and immunity, Vol.77(4), pp.1459-1464
04/2009
Handle:
https://hdl.handle.net/2376/105248
PMCID: PMC2663170
PMID: 19188360
Abstract
Strain superinfection occurs when a second pathogen strain infects a host already carrying a primary strain.
Anaplasma marginale
superinfection occurs when the second strain carries a variant repertoire different from that of the primary strain, and the epidemiologic consequences depend on the relative efficiencies of tick-borne transmission of the two strains. Following strain superinfection in the reservoir host, we tested whether the presence of two
A. marginale
(sensu lato) strains that differed in transmission efficiency altered the transmission phenotypes in comparison to those for single-strain infections.
Dermacentor andersoni
ticks were fed on animals superinfected with the
Anaplasma marginale
subsp.
centrale
vaccine strain (low transmission efficiency) and the
A. marginale
St. Maries strain (high transmission efficiency). Within ticks that acquired both strains, the St. Maries strain had a competitive advantage and replicated to significantly higher levels than the vaccine strain. The St. Maries strain was subsequently transmitted to naïve hosts by ticks previously fed either on superinfected animals or on animals singly infected with the St. Maries strain, consistent with the predicted transmission phenotype of this strain and the lack of interference due to the presence of a competing low-efficiency strain. The vaccine strain was not transmitted by either singly infected or coinfected ticks, consistent with the predicted transmission phenotype and the lack of enhancement due to the presence of a high-efficiency strain. These results support the idea that the strain predominance in regions of endemicity is mediated by the intrinsic transmission efficiency of specific strains regardless of occurrence of superinfection.
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Details
- Title
- Independence of Anaplasma marginale Strains with High and Low Transmission Efficiencies in the Tick Vector following Simultaneous Acquisition by Feeding on a Superinfected Mammalian Reservoir Host
- Creators
- Maria F. B. M Galletti - Program in Vector-Borne Diseases, Department of Veterinary Microbiology and Pathology and School for Global Animal Health, Washington State University, Pullman, Washington 99164Massaro W Ueti - Program in Vector-Borne Diseases, Department of Veterinary Microbiology and Pathology and School for Global Animal Health, Washington State University, Pullman, Washington 99164Donald P Knowles - Program in Vector-Borne Diseases, Department of Veterinary Microbiology and Pathology and School for Global Animal Health, Washington State University, Pullman, Washington 99164Kelly A Brayton - Program in Vector-Borne Diseases, Department of Veterinary Microbiology and Pathology and School for Global Animal Health, Washington State University, Pullman, Washington 99164Guy H Palmer - Program in Vector-Borne Diseases, Department of Veterinary Microbiology and Pathology and School for Global Animal Health, Washington State University, Pullman, Washington 99164
- Publication Details
- Infection and immunity, Vol.77(4), pp.1459-1464
- Academic Unit
- Veterinary Microbiology and Pathology, Department of; Paul G. Allen School for Global Animal Health
- Publisher
- American Society for Microbiology (ASM)
- Identifiers
- 99900547081001842
- Language
- English
- Resource Type
- Journal article