Journal article
Individual antigens of cattle. Differentiation antigens expressed predominantly on CD4- CD8- T lymphocytes (WC1, WC2)
Veterinary immunology and immunopathology, Vol.27(1-3), pp.71-76
01/1991
Handle:
https://hdl.handle.net/2376/107049
PMID: 1708558
Abstract
The 14 mAbs representing workshop cluster 1 recognise a 215/300 kDa antigen expressed on a subpopulation of lymphocytes which express low levels of CD5 but are negative for other B and T cell markers defined by workshop antibodies. Separate studies with cDNA probes for bovine CD3 and T cell receptor indicate that these lymphocytes are gamma/delta T cells. It is of note that the different mAbs react with varying proportions of this cell population, suggesting that the antigen undergoes considerable post-translational modification. A further two mAbs, designated workshop cluster 2, react with a 37/47 kDa heterodimeric molecule expressed in a subpopulation of the WC1+ cells and on an additional small population of T lymphocytes. The cell populations recognised by the two mAbs are different although they overlap in some animals. It is suggested that these mAbs may be specific for T cell receptor molecules.
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Details
- Title
- Individual antigens of cattle. Differentiation antigens expressed predominantly on CD4- CD8- T lymphocytes (WC1, WC2)
- Creators
- W I Morrison - IAH, Compton, Newbury, UKW C Davis
- Publication Details
- Veterinary immunology and immunopathology, Vol.27(1-3), pp.71-76
- Academic Unit
- Veterinary Microbiology and Pathology, Department of
- Publisher
- Netherlands
- Identifiers
- 99900546762201842
- Language
- English
- Resource Type
- Journal article