Journal article
Induction of spermatogenic synchrony by retinoic acid in neonatal mice
Spermatogenesis, Vol.3(1), pp.e23180-e23180
01/01/2013
Handle:
https://hdl.handle.net/2376/104881
PMCID: PMC3644044
PMID: 23687613
Abstract
Retinoic acid (RA) is required for the successful differentiation and meiotic entry of germ cells in the murine testis. The availability of RA to undifferentiated germ cells begins in a variable, uneven pattern during the first few days after birth and establishes the asynchronous pattern of germ cell differentiation in adulthood. It has been shown that synchronous spermatogenesis can be induced in 2 d postpartum mice, but not in adult mice, by treating vitamin A sufficient males with RA. In this study, neonatal males were treated at different ages with a single dose of RA and spermatogenesis was examined after recovery to adulthood. The failure of exogenous RA to alter asynchrony correlates with the appearance of meiotic preleptotene spermatocytes within the seminiferous epithelium.
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Details
- Title
- Induction of spermatogenic synchrony by retinoic acid in neonatal mice
- Creators
- Jeffrey C DavisElizabeth M SnyderCathryn A HogarthChristopher SmallMichael D Griswold
- Publication Details
- Spermatogenesis, Vol.3(1), pp.e23180-e23180
- Academic Unit
- Molecular Biosciences, School of
- Publisher
- Taylor & Francis
- Identifiers
- 99900546880601842
- Language
- English
- Resource Type
- Journal article