Influence of Pentavalent Dopant Addition to Polarization and Bioactivity of Hydroxyapatite

Jharana Dhal; Susmita Bose; Amit Bandyopadhyay

doi:10.1016/j.msec.2013.03.043

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Influence of Pentavalent Dopant Addition to Polarization and Bioactivity of Hydroxyapatite

Journal article

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Influence of Pentavalent Dopant Addition to Polarization and Bioactivity of Hydroxyapatite

Jharana Dhal, Susmita Bose and Amit Bandyopadhyay

Materials science & engineering. C, Materials for biological applications, Vol.33(5), pp.3061-3068

07/01/2013

DOI: https://doi.org/10.1016/j.msec.2013.03.043

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https://hdl.handle.net/2376/109388

PMCID: PMC3694811

PMID: 23623133

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Abstract

Polarization

in-vitro study

Hydroxyapatite

contact angle

osteoblast

tantalum

β-TCP

Influence of pentavalent tantalum doping in bulk hydroxyapatite (HAp) ceramics has been investigated for polarizability and bioactivity. Phase analysis from X-ray diffraction measurement indicates that increasing dopant concentration decreased the amount of HAp phase and increased β-TCP and/or α-TCP phases during sintering at 1250 °C in a muffle furnace. Results from thermally stimulated depolarization current (TSDC) measurements showed that doping hindered charge storage ability in HAp ceramics, and doped samples stored fewer charge compared to pure HAp. However, doping enhanced wettability of HAp samples, which was improved further due to polarization. In vitro human osteoblast cell-materials interactions study revealed an increase in bioactivity due to dopant addition and polarization compared to pure HAp. This increase in bioactivity was attributed to the increase in wettability due to surface charge and dopant addition.

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Title: Influence of Pentavalent Dopant Addition to Polarization and Bioactivity of Hydroxyapatite
Creators: Jharana Dhal - Department of Physics and Astronomy, Washington State University, Pullman, WA 99164
Susmita Bose - W. M. Keck Biomedical materials Research Lab, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164
Amit Bandyopadhyay - W. M. Keck Biomedical materials Research Lab, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164
Publication Details: Materials science & engineering. C, Materials for biological applications, Vol.33(5), pp.3061-3068
Academic Unit: Mechanical and Materials Engineering, School of
Grant note: R01 EB007351 || EB / National Institute of Biomedical Imaging and Bioengineering : NIBIB
Identifiers: 99900547009601842
Language: English
Resource Type: Journal article