Journal article
Influence of bidentate ligand donor types on the formation and stability in 2 + 1 fac-[M I (CO) 3 ] + (M = Re, 99m Tc) complexes
Dalton transactions : an international journal of inorganic chemistry, Vol.46(4), pp.1134-1144
01/24/2017
Handle:
https://hdl.handle.net/2376/107273
PMCID: PMC5287570
PMID: 28045466
Abstract
In the last two decades, a number of chelate strategies have been proposed for the fac-[M
(CO)
]
(M = Re,
Tc) core in radiopharmaceutical applications. However, the development of new ligands/complexes with improved function and in vivo performance has been limited in recent years. Expanding on our previous studies using the 2 + 1 labeling strategy, a series of bidentate ligands (neutral vs. anionic) containing an aromatic amine in combination with monodentate pyridine analogs or imidazole were explored to determine the influence of the bidentate and monodentate ligands on the formation and stability of the respective complexes. The 2 + 1 complexes with Re and
Tc were synthesized in two steps and characterized by standard radio/chemical methods. X-ray characterization and density functional theory analysis of the Re 2 + 1 complexes with the complete bidentate series with 4-dimethylaminopyridine were conducted, indicating enhanced ligand binding energies of the neutral over anionic ligands. In the
Tc studies, anionic bidentate ligands had significantly higher formation yields of the 2 + 1 product, but neutral ligands appear to have increased stability in an amino acid challenge assay. Both bidentate series exhibited improved stability by increasing the basicity of the pyridine ligands.
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Details
- Title
- Influence of bidentate ligand donor types on the formation and stability in 2 + 1 fac-[M I (CO) 3 ] + (M = Re, 99m Tc) complexes
- Creators
- Thomas R Hayes - Washington State University, Department of Chemistry, Pullman, WA 99164, USA. bennyp@wsu.eduShalina C Bottorff - Washington State University, Department of Chemistry, Pullman, WA 99164, USA. bennyp@wsu.eduWinston S Slocumb - Washington State University, Department of Chemistry, Pullman, WA 99164, USA. bennyp@wsu.eduCharles L Barnes - Department of Chemistry, University of Missouri, Columbia, MO 65211, USAAurora E Clark - Washington State University, Department of Chemistry, Pullman, WA 99164, USA. bennyp@wsu.eduPaul D Benny - Washington State University, Department of Chemistry, Pullman, WA 99164, USA. bennyp@wsu.edu
- Publication Details
- Dalton transactions : an international journal of inorganic chemistry, Vol.46(4), pp.1134-1144
- Academic Unit
- Chemistry, Department of
- Publisher
- England
- Grant note
- P20 GM103408 / NIGMS NIH HHS
- Identifiers
- 99900547114001842
- Language
- English
- Resource Type
- Journal article