Journal article
Influence of narcotic antagonist drugs upon nitrous oxide analgesia in mice
Brain research, Vol.440(1), pp.35-41
1988
Handle:
https://hdl.handle.net/2376/103137
PMID: 2833991
Abstract
Nitrous oxide produced a concentration-related suppression of phenylquinone-induced abdominal constriction in mice. This analgesic effect was significantly reduced (but not abolished) by systemic pretreatment with (−)-naloxone or naltrexone but not (+)-naloxone. Systemic pretreament with methylnaltrexone failed to appreciably influence nitrous oxide analgesia: however, methylnaltrexone, administered centrally, significantly attenuated the drug effect. Furthermore, nitrous oxide analgesia was significantly reduced by MR-2266 (which is relatively selective for κ-opioid receptors) but notby β-funaltrexamine (which is selective for μ-opioid receptors) at the doses employed in this study. These findings suggest that nitrous oxide analgesia might involve an activation of κ-opioid receptors in the central nervous system; however, a possible involvement of μ-opioid receptors is not absolutely precluded by this study.
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Details
- Title
- Influence of narcotic antagonist drugs upon nitrous oxide analgesia in mice
- Creators
- Raymond M QuockLesley M Graczak
- Publication Details
- Brain research, Vol.440(1), pp.35-41
- Academic Unit
- Psychology, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900546628901842
- Language
- English
- Resource Type
- Journal article