Influence of porosity on mechanical properties and in vivo response of Ti6Al4V implants

Amit Bandyopadhyay; Felix Espana; Vamsi Krishna Balla; Susmita Bose; Yusuke Ohgami; Neal M Davies

doi:10.1016/j.actbio.2009.11.011

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Influence of porosity on mechanical properties and in vivo response of Ti6Al4V implants

Journal article

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Influence of porosity on mechanical properties and in vivo response of Ti6Al4V implants

Amit Bandyopadhyay, Felix Espana, Vamsi Krishna Balla, Susmita Bose, Yusuke Ohgami and Neal M Davies

Acta biomaterialia, Vol.6(4), pp.1640-1648

2010

DOI: https://doi.org/10.1016/j.actbio.2009.11.011

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https://hdl.handle.net/2376/105491

PMCID: PMC2830321

PMID: 19913643

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Abstract

Porous Ti6Al4V

Mechanical properties

In vivo behavior

Laser engineered net shaping (LENS)

Metallic biomaterials are widely used to restore the lost structure and functions of human bone. Due to the large number of joint replacements, there is a growing demand for new and improved orthopedic implants. More specifically, there is a need for novel load-bearing metallic implants with low effective modulus matching that of bone in order to reduce stress shielding and consequently increase the in vivo lifespan of the implant. In this study, we have fabricated porous Ti6Al4V alloy structures, using laser engineered net shaping (LENS™), to demonstrate that advanced manufacturing techniques such as LENS™ can be used to fabricate low-modulus, tailored porosity implants with a wide variety of metals/alloys, where the porosity can be designed in areas based on the patient’s need to enhance biological fixation and achieve long-term in vivo stability. The effective modulus of Ti6Al4V alloy structures has been tailored between 7 and 60 GPa and porous Ti alloy structures containing 23–32 vol.% porosity showed modulus equivalent to human cortical bone. In vivo behavior of porous Ti6Al4V alloy samples in male Sprague–Dawley rats for 16 weeks demonstrated a significant increase in calcium within the implants, indicating excellent biological tissue ingrowth through interconnected porosity. In vivo results also showed that total amount of porosity plays an important role in tissue ingrowth.

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Title: Influence of porosity on mechanical properties and in vivo response of Ti6Al4V implants
Creators: Amit Bandyopadhyay - W.M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164-2920, USA
Felix Espana - W.M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164-2920, USA
Vamsi Krishna Balla - W.M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164-2920, USA
Susmita Bose - W.M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164-2920, USA
Yusuke Ohgami - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, WA 99164-6534, USA
Neal M Davies - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, WA 99164-6534, USA
Publication Details: Acta biomaterialia, Vol.6(4), pp.1640-1648
Academic Unit: Mechanical and Materials Engineering, School of
Publisher: Elsevier Ltd
Identifiers: 99900546775901842
Language: English
Resource Type: Journal article