Journal article
Influenza virus- and cytokine-immunoreactive cells in the murine olfactory and central autonomic nervous systems before and after illness onset
Journal of neuroimmunology, Vol.211(1), pp.73-83
2009
Handle:
https://hdl.handle.net/2376/107508
PMCID: PMC2696569
PMID: 19410300
Abstract
Influenza virus invades the olfactory bulb (OB) and enhances cytokine mRNAs therein at the time of illness onset. Here we show that viral antigen immunoreactivity co-localized with glial markers in the OB but could not be detected in other brain areas. Interleukin 1β- and tumor necrosis factor α-immunoreactivity co-localized with neuronal markers in olfactory and central autonomic systems, and the number of cytokine-immunoreactive neurons increased at the time of illness onset [15 h post-inoculation (PI)] but not before (10 h PI). These results suggest that the OB virus influences the brain cytokines and therefore the onset of illness.
Metrics
12 Record Views
Details
- Title
- Influenza virus- and cytokine-immunoreactive cells in the murine olfactory and central autonomic nervous systems before and after illness onset
- Creators
- Victor H Leyva-GradoLynn ChurchillMelissa WuTimothy J WilliamsPing TaishiJeannine A MajdeJames M Krueger
- Publication Details
- Journal of neuroimmunology, Vol.211(1), pp.73-83
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900547333301842
- Language
- English
- Resource Type
- Journal article