Journal article
Influenza virus-induced glucocorticoid and hypothalamic and lung cytokine mRNA responses in dwarf lit/ lit mice
Brain, behavior, and immunity, Vol.21(1), pp.60-67
2007
Handle:
https://hdl.handle.net/2376/105812
PMID: 15951155
Abstract
Influenza virus infection up-regulates cytokines such as interleukin-1β (IL-1β) and activates the somatotropic axis and the hypothalamic–pituitary axis. Mice with deficits in growth hormone releasing hormone (GHRH) signaling (
lit/
lit mice) respond to influenza virus challenge with a progressive decrease in sleep and lower survival rates. Current experiments characterize plasma glucocorticoid responses and hypothalamic and lung mRNA expression of sleep-related genes in
lit/
lit mice and their heterozygous controls after influenza virus challenge.
lit/
lit mice had higher basal and post-infection plasma corticosterone levels compared to controls. In contrast, the heterozygous mice increased hypothalamic GHRH-receptor, CRH-type 2 receptor, IL-1β, and tumor necrosis factor-α (TNF-α) mRNAs after virus treatment while the
lit/
lit mice failed to up-regulate these substances. In contrast, lung levels of IL-1β and TNF-α mRNAs were greater in the
lit/
lit mice. These data are consistent with the hypothesis that the sleep response to influenza infection is mediated, in part, by an up-regulation of hypothalamic sleep-related transcripts and they also show that a primary deficit in GHRH signaling is associated with enhanced corticosterone secretion and attenuated hypothalamic cytokine response to infection.
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Details
- Title
- Influenza virus-induced glucocorticoid and hypothalamic and lung cytokine mRNA responses in dwarf lit/ lit mice
- Creators
- Jeremiah A Alt - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164-6520, USAStewart Bohnet - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164-6520, USAPing Taishi - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164-6520, USADeborah Duricka - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164-6520, USAFerenc Obal - Department of Physiology, University of Szeged, A. Szent-Györgyi Medical Center, 6720 Szeged, HungaryTim Traynor - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164-6520, USAJeannine A Majde - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164-6520, USAJames M Krueger - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164-6520, USA
- Publication Details
- Brain, behavior, and immunity, Vol.21(1), pp.60-67
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900547146501842
- Language
- English
- Resource Type
- Journal article