Journal article
Inhibiting vitamin A metabolism as an approach to male contraception
Trends in endocrinology and metabolism, Vol.22(4), pp.136-144
2011
Handle:
https://hdl.handle.net/2376/105892
PMCID: PMC3070762
PMID: 21277790
Abstract
Although oral contraceptives have been available to women since the 1960s, contraceptive options for men have remained limited. Spermatogenesis relies on the active metabolite of vitamin A, retinoic acid, to drive spermatogonial differentiation and to allow the production of normal numbers of sperm. Recent evidence describes how the enzymes which control vitamin A metabolism in the testis could be targeted to generate effective male contraceptives; however, the detailed mechanism(s) regarding how vitamin A regulates normal spermatogenesis are still unknown. The essential nature of vitamin A to male germ cell development and the prospects of developing the proteins responsible for the generation, transport, and storage of retinoic acid as targets for male contraceptive development are discussed in this review.
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Details
- Title
- Inhibiting vitamin A metabolism as an approach to male contraception
- Creators
- Cathryn A Hogarth - School of Molecular Biosciences, Washington State University, Pullman, WA, USAJohn K Amory - University of Washington Medical Center, University of Washington, Seattle, WA, USAMichael D Griswold - School of Molecular Biosciences, Washington State University, Pullman, WA, USA
- Publication Details
- Trends in endocrinology and metabolism, Vol.22(4), pp.136-144
- Academic Unit
- Molecular Biosciences, School of
- Publisher
- Elsevier Ltd
- Identifiers
- 99900546898901842
- Language
- English
- Resource Type
- Journal article