Journal article
Inhibition of brain interleukin-1 attenuates sleep rebound after sleep deprivation in rabbits
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.273(2), pp.R677-R682
08/01/1997
Handle:
https://hdl.handle.net/2376/115086
PMID: 9277554
Abstract
It is hypothesized that interleukin-1 (IL-1) is involved in physiological sleep. If this hypothesis is correct, inhibition of IL-1 should attenuate sleep responses after sleep deprivation. We tested the effect of intracerebroventricular or intravenous injection of an IL-1 inhibitor, an IL-1 receptor fragment (IL-1RF), on sleep rebound after sleep deprivation in rabbits. Six hours of total sleep deprivation significantly increased non-rapid eye movement sleep (NREMS) and enhanced electroencephalogram slow-wave activity during NREMS. Intracerebroventricular treatment with the IL-1RF (50 micrograms) significantly attenuated the sleep responses after sleep deprivation. Furthermore, 1.0 mg/kg i.v. injection of the IL-1RF significantly suppressed spontaneous NREMS in rabbits that were not sleep deprived. However, intravenous administration of the IL-1RF (1.0 mg/kg) failed to attenuate the sleep responses following the 6-h sleep deprivation period. These results support the hypothesis that central pools of IL-1 are important for physiological sleep regulation.
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Details
- Title
- Inhibition of brain interleukin-1 attenuates sleep rebound after sleep deprivation in rabbits
- Creators
- S Takahashi - Department of Physiology and Biophysics, University of Tennessee,Memphis 38163, USAJ Fang - Department of Physiology and Biophysics, University of Tennessee,Memphis 38163, USAL Kapas - Department of Physiology and Biophysics, University of Tennessee,Memphis 38163, USAY Wang - Department of Physiology and Biophysics, University of Tennessee,Memphis 38163, USAJ. M Krueger - Department of Physiology and Biophysics, University of Tennessee,Memphis 38163, USA
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.273(2), pp.R677-R682
- Academic Unit
- Biomedical Sciences, Department of; Integrative Physiology and Neuroscience, Department of
- Identifiers
- 99900548227401842
- Language
- English
- Resource Type
- Journal article