Journal article
Inhibition of tumor necrosis factor attenuates physiological sleep in rabbits
Neuroreport, Vol.7(2), pp.642-646
01/31/1996
Handle:
https://hdl.handle.net/2376/115506
PMID: 8730848
Abstract
The involvement of tumor necrosis factor (TNF) in sleep regulation was investigated by blocking TNF using a synthetic TNF receptor fragment (TNFRF) in rabbits. Intracerebroventricular injection of 50 μg TNFRF decreased spontaneous non-rapid-eye-movement (NREM) sleep across the 21 h recording period. After 6 h of sleep deprivation (SD), both duration of NREM sleep and electroencephalographic (EEG) slow wave activity during NREM sleep were enhanced. TNFRF suppressed SD- enhanced NREM sleep and EEG slow wave activity. SD per se did not affect rapid-eye-movement (REM) sleep, but TNFRF treatment increased REM sleep after SD. These results are consistent with the hypothesis that TNF is involved in the regulation of physiological NREM sleep.
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Details
- Title
- Inhibition of tumor necrosis factor attenuates physiological sleep in rabbits
- Creators
- Satoshi Takahashi - Departments of Physiology and Biophysics, and Biochemistry, University of Tennessee, 894 Union Avenue, Memphis, TN 38163, USA Permanent address: Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki 036, JapanLevente KapásJerome SeyerYing WangJames Krueger
- Publication Details
- Neuroreport, Vol.7(2), pp.642-646
- Academic Unit
- Biomedical Sciences, Department of; Integrative Physiology and Neuroscience, Department of
- Publisher
- Lippincott-Raven Publishers
- Identifiers
- 99900548052301842
- Language
- English
- Resource Type
- Journal article