Journal article
Inhibition of tumor necrosis factor prevents warming-induced sleep responses in rabbits
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.272(4), pp.R1325-R1329
04/01/1997
Handle:
https://hdl.handle.net/2376/115405
PMID: 9140036
Abstract
Tumor necrosis factor (TNF) is a key regulatory component of sleep. In the present study, we determined the effects of intracerebroventricular injection of a TNF inhibitor, a soluble TNF receptor fragment (TNF-RF), on sleep responses of rabbits during and after exposure to mild increases in ambient temperature (T(amb)). Each rabbit (n = 8) was recorded under three conditions: 1) normal T(amb) (21 degrees C) with pyrogen-free saline (PFS), 50 microl i.c.v.; 2) 27 degrees C T(amb) with PFS, intracerebroventricularly; and 3) 27 degrees C T(amb) with the TNF-RF, 50 microg i.c.v. When T(amb) was increased to 27 degrees C from 21 degrees C, it was kept at that temperature for 6 h after injection. The higher T(amb) alone significantly increased non-rapid eye movement sleep, decreased rapid eye movement sleep, and increased brain temperature (T(br)) across the 23-h recording period. Electroencephalogram slow-wave activity was also significantly enhanced during the 6-h warming period. In contrast, all of the sleep responses associated with the higher T(amb) were absent if rabbits were pretreated with the TNF-RF. The elevated T(br) during the higher T(amb) was not affected by the TNF-RF. The present results suggest that brain TNF is involved in the mild increases in T(amb)-induced sleep responses.
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Details
- Title
- Inhibition of tumor necrosis factor prevents warming-induced sleep responses in rabbits
- Creators
- S Takahashi - Department of Physiology and Biophysics, University of Tennessee,Memphis 38163, USAJ. M Krueger - Department of Physiology and Biophysics, University of Tennessee,Memphis 38163, USA
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.272(4), pp.R1325-R1329
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Identifiers
- 99900547309601842
- Language
- English
- Resource Type
- Journal article