Journal article
Insights from zebrafish on human pigment cell disease and treatment
Developmental dynamics, Vol.246(11), pp.889-896
11/2017
Handle:
https://hdl.handle.net/2376/106855
PMID: 28710811
Abstract
Black pigment cells, melanocytes, arise early during development from multipotent neural crest cells. Melanocytes protect human skin from DNA damaging sunrays and provide color for hair, eyes, and skin. Several disorders and diseases originate from these cells, including the deadliest skin cell cancer, melanoma. Thus, melanocytes are critical for a healthy life and for protecting humans from disease. Due to the ease of visualizing pigment cells through transparent larvae skin and conserved roles for zebrafish melanophore genes to mammalian melanocyte genes, zebrafish larvae offer a biologically relevant model for understanding pigment cell development and disease in humans. This review discusses our current knowledge of melanophore biology and how zebrafish are contributing to improving how diseases of melanocytes are understood and treated in humans. Developmental Dynamics 246:889–896, 2017. © 2017 Wiley Periodicals, Inc.
Key Findings
This manuscript reviews the current status of melanocyte biology, melanocyte disorders and the benefits of using zebrafish to study both topics.
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Details
- Title
- Insights from zebrafish on human pigment cell disease and treatment
- Creators
- Cynthia D Cooper - Washington State University Vancouver
- Publication Details
- Developmental dynamics, Vol.246(11), pp.889-896
- Academic Unit
- Molecular Biosciences, School of
- Number of pages
- 8
- Identifiers
- 99900546979701842
- Language
- English
- Resource Type
- Journal article