Journal article
Interindividual differences in the dynamics of the homeostatic process are trait‐like and distinct for sleep versus wakefulness
Journal of sleep research, Vol.26(2), pp.171-178
04/2017
Handle:
https://hdl.handle.net/2376/108173
PMID: 28019041
Abstract
Summary
The sleep homeostatic Process S reflects the build‐up of sleep pressure during waking and its dissipation during sleep. Process S is modelled as a saturating exponential function during waking and a decreasing exponential function during sleep. Slow wave activity is a physiological marker for non‐rapid eye movement (non‐REM) sleep intensity and serves as an index of Process S. There is considerable interindividual variability in the sleep homeostatic responses to sleep and sleep deprivation. The aim of this study was to investigate whether interindividual differences in Process S are trait‐like. Polysomnographic recordings of 8 nights (12‐h sleep opportunities, 22:00–10:00 hours) interspersed with three 36‐h periods of sustained wakefulness were performed in 11 healthy young adults. Empirical mean slow wave activity per non‐REM sleep episode at episode mid‐points were used for parameter estimation. Parameters of Process S were estimated using different combinations of consecutive sleep recordings, resulting in two to three sets of parameters per subject. Intraclass correlation coefficients were calculated to assess whether the parameters were stable across the study protocol and they showed trait‐like variability among individuals. We found that the group‐average time constants of the build‐up and dissipation of Process S were 19.2 and 2.7 h, respectively. Intraclass correlation coefficients ranged from 0.48 to 0.56, which reflects moderate trait variability. The time constants of the build‐up and dissipation varied independently among subjects, indicating two distinct traits. We conclude that interindividual differences in the parameters of the dynamics of the sleep homeostatic Process S are trait‐like.
Metrics
8 Record Views
Details
- Title
- Interindividual differences in the dynamics of the homeostatic process are trait‐like and distinct for sleep versus wakefulness
- Creators
- Thomas Rusterholz - University of BernLeila Tarokh - The Alpert Medical School of Brown UniversityHans P. A Van Dongen - Washington State UniversityPeter Achermann - University and ETH Zurich
- Publication Details
- Journal of sleep research, Vol.26(2), pp.171-178
- Academic Unit
- Medical Education and Clinical Science, Department of
- Number of pages
- 8
- Grant note
- Swiss National Science Foundation (320030‐130766; 32003B_146643) NIH (R01HL070154)
- Identifiers
- 99900546954201842
- Language
- English
- Resource Type
- Journal article