Journal article
Interleukin 1 alters rat sleep: temporal and dose-related effects
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.260(1), pp.R52-R58
01/01/1991
Handle:
https://hdl.handle.net/2376/110250
PMID: 1992828
Abstract
Rats received various doses of interleukin 1 (IL-1) (range, 0.5-25.0 ng) or pyrogen-free saline intracerebroventricularly during the rest (light) and the active (dark) cycles of the day, and sleep-wake activity and brain temperature were determined for 6 h. Low doses of IL-1 (0.5 ng at night, 2.5 ng during the day) increased both the duration of non-rapid-eye-movement sleep (NREMS) and electroencephalogram (EEG) slow-wave activity during NREMS episodes. Increasing doses of IL-1 had divergent effects on NREMS duration and EEG slow-wave activity, and the direction of the changes depended on the diurnal cycle. Thus NREMS duration was promoted at night and EEG slow-wave amplitudes during the day, whereas NREMS duration during the day and EEG slow-wave amplitudes at night were suppressed after higher doses of IL-1. High doses of IL-1 also induced decreases in rapid-eye-movement sleep during both phases of the day. Each dose of IL-1 that promoted NREMS also tended to increase brain temperature. These results demonstrate that IL-1 promotes NREMS in the rat. However, unlike previously reported findings in rabbits, the circadian rhythm of sleep regulation strongly interferes with the sleep-promoting activity of IL-1 in rats.
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Details
- Title
- Interleukin 1 alters rat sleep: temporal and dose-related effects
- Creators
- M. R Opp - Department of Physiology and Biophysics, University of Tennessee,Memphis 38163F Obal - Department of Physiology and Biophysics, University of Tennessee,Memphis 38163J. M Krueger - Department of Physiology and Biophysics, University of Tennessee,Memphis 38163
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.260(1), pp.R52-R58
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Identifiers
- 99900547110501842
- Language
- English
- Resource Type
- Journal article