Journal article
Interleukin-1-induced sleep and febrile responses differentially altered by a muramyl dipeptide derivative
International journal of immunopharmacology, Vol.11(8), pp.887-893
1989
Handle:
https://hdl.handle.net/2376/104848
PMID: 2613394
Abstract
Muramyl dipeptide (
N-
acetylmuramyl-
L
-
alanyl-
D
-
isoglutamine;
AcMur-
L
-
Ala-
D
-
iGln;
MDP
) is a somnogenic, pyrogenic, and immunoadjuvant component of bacterial cell wall peptidoglycan. It enhances the production of the cytokine interleukin 1 (IL-1)
in vivo and
in vitro; IL-1 itself is somnogenic and pyrogenic. The pyrogenic effects of IL-1 may be separated from its somnogenicity by the use of antipyretics. A methyl ester derivative of MDP (murametide; AcMur-
L-Ala-
D-Gln-α-methyl ester) blocks IL-1-induced fever, but induces IL-1 production/release. Therefore, the effects of murametide on IL-1-induced sleep and fever responses were determined. Rabbits were pretreated with intravenous injections of murametide 0,30 or 60 min before intravenous injection of a pyrogenic/somnogenic dose of recombinant IL-1β (rIL-1β). Murametide alone produced no effects on sleep or brain temperatures. Murametide given simultaneously with rIL-1β potentiated increases of brain temperature, whereas when there was a 60 min delay between the injection of murametide and rIL-1β, responses were similar to those induced by rIL-1β alone. Murametide given 30 min before rIL-1β, blocked the expected IL-1-induced fevers but not the rIL-1β-mediated increased of slow-wave sleep and decreases of rapid-eye-movement sleep. These results reinforce the conclusion that, in part, independent brain mechanisms are involved in the somnogenic and pyrogenic actions of IL-1.
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Details
- Title
- Interleukin-1-induced sleep and febrile responses differentially altered by a muramyl dipeptide derivative
- Creators
- Alan B Cady - Department of Physiology and Biophysics, University of Tennessee, Memphis, 894 Union Avenue, Memphis, Tennessee 38163, USAGilles Riveau - Department of Pharmacology and Therapeutics, University of South Florida, Tampa, Florida 33612, USALouis Chedid - Department of Pharmacology and Therapeutics, University of South Florida, Tampa, Florida 33612, USACharles A Dinarello - Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111, U.S.ALars Johannsen - Department of Physiology and Biophysics, University of Tennessee, Memphis, 894 Union Avenue, Memphis, Tennessee 38163, USAJames M Krueger - Department of Physiology and Biophysics, University of Tennessee, Memphis, 894 Union Avenue, Memphis, Tennessee 38163, USA
- Publication Details
- International journal of immunopharmacology, Vol.11(8), pp.887-893
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier Science
- Identifiers
- 99900546649001842
- Language
- English
- Resource Type
- Journal article