Journal article
Interleukin-1 is involved in responses to sleep deprivation in the rabbit
Brain research, Vol.639(1), pp.57-65
1994
Handle:
https://hdl.handle.net/2376/109670
PMID: 8180839
Abstract
Interleukin-1 (IL-1) is hypothesized to be involved in sleep regulation. Antibodies directed against interleukin-1β (anti-IL-1β) were injected intracerebroventicularly (ICV) into normal rabbits to determine the effects of the reduction of endogenous IL-1β on spontaneous sleep/wake behaviour. A 100 μg dose of anti-IL-1β reduced non-rapid eye movements sleep (NREMS) by about 20-min during the first 4-h postinjection without affecting REMS, amplitudes of eletroencephalographic (EEG) slow waves, or brain temperature. Plasma concentrations of IL-1β, as determined by radiomunoassay, were detectable in 39 of 79 (49%) blood samples taken before and after 4-h total sleep deprivation (SD). Plasma concentrations of IL-1β were, on average, significantly elevated following SD. There was a rebound in NREMS duration and of amplitudes of EEG slow waves of about 2-h duration following SD. This rebound in both parameters was exaggerated if rabbits received vehicle or anti-IL-1β in conjunction with SD. However, ICV administration of anti-IL-1β at the beginning or end of the SD period attenuated, relative to values obtained after administration of vehicle, the NREMS rebound following SD. It is concluded that SD alters the responsiveness of rabbits to experimental manipulation and that responses to SD in the rabbit are mediated, in part, by IL-1.
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Details
- Title
- Interleukin-1 is involved in responses to sleep deprivation in the rabbit
- Creators
- Mark R OppJames M Krueger
- Publication Details
- Brain research, Vol.639(1), pp.57-65
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900547158601842
- Language
- English
- Resource Type
- Journal article