Journal article
Interleukin 1-receptor antagonist blocks interleukin 1-induced sleep and fever
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.260(2), pp.R453-R457
02/01/1991
Handle:
https://hdl.handle.net/2376/112559
PMID: 1825458
Abstract
The recent purification and characterization of an interleukin 1-receptor antagonist (IL-1ra) has provided an additional means of elucidating the mechanisms involved in the responses initiated by IL-1. Central administration of IL-1 to rabbits results in a characteristic febrile response and in increased non-rapid-eye-movement sleep (NREMS). In this study, rabbits received various doses of IL-1ra (10-1,000 micrograms) or pyrogen-free saline intracerebroventricularly, and sleep-wake activity and brain temperature (Tbr) were determined for the next 24 h. All doses of IL-1ra tested tended to reduce NREMS in the first postinjection hour with little effect on Tbr. When rabbits were pretreated with 100 micrograms IL-1ra and then injected with 10 ng IL-1, the characteristic IL-1-induced febrile and NREMS-promoting effects were completely blocked.
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Details
- Title
- Interleukin 1-receptor antagonist blocks interleukin 1-induced sleep and fever
- Creators
- M. R Opp - Department of Physiology and Biophysics, University of Tennessee,Memphis 38163J. M Krueger - Department of Physiology and Biophysics, University of Tennessee,Memphis 38163
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.260(2), pp.R453-R457
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Identifiers
- 99900548046301842
- Language
- English
- Resource Type
- Journal article