Journal article
Interleukin-13 and transforming growth factor-beta 1 inhibit spontaneous sleep in rabbits
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.279(3), pp.786-R792
09/01/2000
Handle:
https://hdl.handle.net/2376/114719
PMID: 10956235
Abstract
Washington State University, College of Veterinary Medicine,
Department of Veterinary and Comparative Anatomy, Pharmacology and
Physiology, Pullman, Washington 99164
Proinflammatory cytokines,
including interleukin-1 and tumor necrosis factor- are involved
in physiological sleep regulation. Interleukin (IL)-13 and transforming
growth factor (TGF)- 1 are anti-inflammatory cytokines that inhibit
proinflammatory cytokines by several mechanisms. Therefore, we
hypothesized that IL-13 and TGF- 1 could attenuate sleep in rabbits.
Three doses of IL-13 (8, 40, and 200 ng) and TGF- 1 (40, 100, and 200 ng) were injected intracerebroventricularly 3 h after the
beginning of the light period. In addition, one dose of IL-13 (200 ng)
and one dose of TGF- 1 (200 ng) were injected at dark onset. The two
higher doses of IL-13 and the highest dose of TGF- 1 significantly
inhibited spontanenous non-rapid eye movement sleep (NREMS) when they
were given in the light period. IL-13 also inhibited NREMS after dark onset administration; however, the inhibitory effect was less potent
than that observed after light period administration. The 40-ng dose of
IL-13 inhibited REMS duration during the dark period. TGF- 1
administered at dark onset had no effect on sleep. These data provide
additional evidence for the hypothesis that a brain cytokine network is
involved in regulation of physiological sleep.
non-rapid eye movement sleep; electroencephalogram; cytokine; brain
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Details
- Title
- Interleukin-13 and transforming growth factor-beta 1 inhibit spontaneous sleep in rabbits
- Creators
- Takeshi KubotaJidong FangTetsuya KushikataJames M Krueger
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.279(3), pp.786-R792
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Identifiers
- 99900547877901842
- Language
- English
- Resource Type
- Journal article