Journal article
Interleukin-18 promotes sleep in rabbits and rats
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.281(3), pp.R828-R838
09/01/2001
Handle:
https://hdl.handle.net/2376/115219
PMID: 11506998
Abstract
Interleukin (IL)-1β is involved in physiological sleep regulation. IL-18 is a member of the IL-1 family, and its signal-transduction mechanism is similar to that of IL-1. Therefore, we hypothesized that IL-18 might also be involved in sleep regulation. Three doses of IL-18 (10, 100, and 500 ng) were injected intracerebroventricularly (icv) into rabbits at the onset of the dark period. The two higher doses of IL-18 markedly increased non-rapid eye movement sleep (NREMS), accompanied by increases in brain temperature (Tbr). These effects were lost after the heat inactivation of IL-18. The 500 ng of IL-18 injection during the light period also increased NREMS and Tbr. Similar results were obtained after icv injection of 100 ng of IL-18 into rats. Furthermore, intraperitoneal injection of 30 μg/kg of IL-18 slightly, but significantly, increased NREMS, whereas it significantly decreased electroencephalogram slow-wave activity in rats. Intraperitoneal IL-18 failed to induce fever. An anti-human IL-18 antibody had little effect on spontaneous sleep in rabbits, although the anti-IL-18 antibody significantly attenuated muramyl dipeptide-induced sleep. These data suggest that IL-18 is involved in mechanisms of sleep responses to infection.
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Details
- Title
- Interleukin-18 promotes sleep in rabbits and rats
- Creators
- Takeshi Kubota - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington 99164 – 6520Jidong Fang - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington 99164 – 6520Richard A Brown - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington 99164 – 6520James M Krueger - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington 99164 – 6520
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.281(3), pp.R828-R838
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Identifiers
- 99900548501401842
- Language
- English
- Resource Type
- Journal article