Journal article
Interleukin-4 inhibits spontaneous sleep in rabbits
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.275(4), pp.R1185-R1191
10/01/1998
Handle:
https://hdl.handle.net/2376/108729
PMID: 9756549
Abstract
Proinflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor-α, are involved in sleep regulation. IL-4 is an antiinflammatory cytokine that inhibits proinflammatory cytokine production. The hypothesis that IL-4 should attenuate sleep was studied by determining the effects of IL-4 on rabbit spontaneous sleep. Thirty-six rabbits were used. Four doses of IL-4 (0.25, 2.5, 25, and 250 ng) were injected intracerebroventricularly during the rest (light) period. One dose of IL-4 (25 ng) was injected during the active (dark) cycle. Appropriate time-matched control injections of saline were done in the same rabbits on different days. The three highest doses of IL-4 significantly inhibited spontaneous non-rapid eye movement sleep if IL-4 was given during the light cycle. The highest dose of IL-4 (250 ng) also significantly decreased rapid eye movement sleep. On the other hand, IL-4 administered at dark onset had no effect on sleep. The sleep inhibitory properties of IL-4 provide additional evidence for the hypothesis that a brain cytokine network is involved in the regulation of physiological sleep.
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Details
- Title
- Interleukin-4 inhibits spontaneous sleep in rabbits
- Creators
- Tetsuya Kushikata - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington 99164; andJidong Fang - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington 99164; andYing Wang - Department of Physiology, The University of Tennessee, Memphis, Tennessee 38163James M Krueger - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington 99164; and
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.275(4), pp.R1185-R1191
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Identifiers
- 99900547353701842
- Language
- English
- Resource Type
- Journal article