Journal article
International Lung Cancer Consortium: Coordinated association study of 10 potential lung cancer susceptibility variants
Carcinogenesis (New York), Vol.31(4), pp.625-633
04/2010
Handle:
https://hdl.handle.net/2376/101762
PMCID: PMC2847090
PMID: 20106900
Abstract
Background
. Analysis of candidate genes in individual studies has had only limited success in identifying particular gene variants that are conclusively associated with lung cancer risk. In the International Lung Cancer Consortium (ILCCO), we conducted a coordinated genotyping study of 10 common variants selected because of their prior evidence of an association with lung cancer. These variants belonged to candidate genes from different cancer-related pathways including inflammation (
IL1B
), folate metabolism (
MTHFR
), regulatory function (
AKAP9
and
CAMKK1
), cell adhesion (
SEZL6
) and apoptosis (
FAS
,
FASL
,
TP53
,
TP53BP1
and
BAT3
).
Methods.
Genotype data from 15 ILCCO case–control studies were available for a total of 8431 lung cancer cases and 11 072 controls of European descent and Asian ethnic groups. Unconditional logistic regression was used to model the association between each variant and lung cancer risk.
Results
. Only the association between a non-synonymous variant of
TP53BP1
(rs560191) and lung cancer risk was significant (OR = 0.91,
P
= 0.002). This association was more striking for squamous cell carcinoma (OR = 0.86,
P
= 6 × 10
−4
). No heterogeneity by center, ethnicity, smoking status, age group or sex was observed. In order to confirm this association, we included results for this variant from a set of independent studies (9966 cases/11 722 controls) and we reported similar results. When combining all these studies together, we reported an overall OR = 0.93 (0.89–0.97) (
P
= 0.001). This association was significant only for squamous cell carcinoma [OR = 0.89 (0.85–0.95),
P
= 1 × 10
−4
].
Conclusion.
This study suggests that rs560191 is associated to lung cancer risk and further highlights the value of consortia in replicating or refuting published genetic associations.
Metrics
10 Record Views
Details
- Title
- International Lung Cancer Consortium: Coordinated association study of 10 potential lung cancer susceptibility variants
- Creators
- Therese Truong - International Agency for Research on Cancer, Lyon 69008, FranceWiebke Sauter - Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, GermanyJames D McKay - International Agency for Research on Cancer, Lyon 69008, FranceH.Dean Hosgood - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USACarla Gallagher - Penn State College of Medicine, Hershey, PA 17033, USAChristopher I Amos - University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USAMargaret Spitz - University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USAJoshua Muscat - Penn State College of Medicine, Hershey, PA 17033, USAPhilip Lazarus - Penn State College of Medicine, Hershey, PA 17033, USAThomas Illig - Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, GermanyH.Erich Wichmann - Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, GermanyHeike Bickeböller - University of Goettingen, Medical School, 37073 Goettingen, GermanyAngela Risch - DKFZ German Cancer Research Center, 69120 Heidelberg, GermanyHendrik Dienemann - Thoraxklinik Heidelberg, University of Heidelberg, 69126 Heidelberg, GermanyZuo-Feng Zhang - University of California at Los Angeles, Los Angeles, CA 90095-1772, USABehnaz Pezeshki Naeim - University of California at Los Angeles, Los Angeles, CA 90095-1772, USAPing Yang - Mayo Clinic Cancer Center, Rochester, MN 55905, USAShanbeh Zienolddiny - National Institute of Occupational Health, 0167 Oslo, NorwayAage Haugen - National Institute of Occupational Health, 0167 Oslo, NorwayLoïc Le Marchand - University of Hawaii, Honolulu, HI 9681, USAYun-Chul Hong - Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 110-799, Republic of KoreaJin Hee Kim - Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 110-799, Republic of KoreaEric J Duell - International Agency for Research on Cancer, Lyon 69008, FranceAngeline S Andrew - Norris Cotton Cancer Center and Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03756, USAChikako Kiyohara - Kyushu University, Fukuoka 812-8582, JapanHongbing Shen - Nanjing Medical University School of Public Health, Nanjing 210029, ChinaKeitaro Matsuo - Aichi Cancer Center Research Institute, Nagoya Aichi 464-8681, JapanTakeshi Suzuki - Aichi Cancer Center Research Institute, Nagoya Aichi 464-8681, JapanAdeline Seow - Department of Community, Occupational and Family Medicine. National University of Singapore, Singapore 117597, SingaporeDaniel P.K Ng - Department of Community, Occupational and Family Medicine. National University of Singapore, Singapore 117597, SingaporeQing Lan - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USADavid Zaridze - Institute of carcinogenesis, cancer research center, Moscow 115478, RussiaNeonilia Szeszenia-Dabrowska - Department of Epidemiology, Institute of occupational medecine, Lodz 90950, PolandJolanta Lissowska - The M. Sklodowska-Curie memorial cancer center and institute of oncology, Warsaw 02781, PolandPeter Rudnai - National institute of environmental health, Budapest 1097, HungaryEleonora Fabianova - Specialized Institute of Hygiene and Epidemiology, 97556 Banská Bystrica, SlovakiaVali Constantinescu - Institute of Public Health, Bucharest 050463, RomaniaVladimir Bencko - Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University in Prague, CZ 12800, Czech RepublicLenka Foretova - Department of cancer epidemiology and genetics, Masaryk Memorial cancer institute, Brno 65653, Czech RepublicVladimir Janout - Palacky University, Olomouc 77515, Czech RepublicNeil E Caporaso - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USADemetrius Albanes - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USAMichael Thun - American Cancer Society, Epidemiology and Surveillance Research, Atlanta, GA 30301, USAMaria Teresa Landi - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USAJoanna Trubicka - Department of Genetics and Pathomorphology, Pomeranian Medical University, International Hereditary Cancer Center, 70-204 Szczecin, PolandMarcin Lener - Department of Genetics and Pathomorphology, Pomeranian Medical University, International Hereditary Cancer Center, 70-204 Szczecin, PolandJan Lubiński - Department of Genetics and Pathomorphology, Pomeranian Medical University, International Hereditary Cancer Center, 70-204 Szczecin, PolandYing Wang - Samuel Lununfeld Research Institute, Toronto M5T 3L9, CanadaAmélie Chabrier - International Agency for Research on Cancer, Lyon 69008, FrancePaolo Boffetta - International Agency for Research on Cancer, Lyon 69008, FrancePaul Brennan - International Agency for Research on Cancer, Lyon 69008, FranceRayjean J Hung - International Agency for Research on Cancer, Lyon 69008, France
- Publication Details
- Carcinogenesis (New York), Vol.31(4), pp.625-633
- Academic Unit
- Pharmaceutical Sciences, Department of
- Publisher
- Oxford University Press
- Identifiers
- 99900546648101842
- Language
- English
- Resource Type
- Journal article