Journal article
Interstrain conservation of babesial RAP-1 surface-exposed B-cell epitopes despite rap-1 genomic polymorphism
Infection and immunity, Vol.62(8), pp.3576-3579
08/1994
Handle:
https://hdl.handle.net/2376/107211
PMCID: PMC302997
PMID: 7518810
Abstract
Members of the babesial rhoptry-associated protein 1 (RAP-1) family express surface-exposed B-cell epitopes and are candidate antigens for vaccine development. The relationship between rap-1 genomic polymorphism and surface-exposed B-cell epitope expression was analyzed by comparison of biological clones of Mexico strain Babesia bigemina and Babesia bovis with strains isolated in Argentina. Despite genomic polymorphism between strains, including sequences located within the open reading frame, defined RAP-1 B-cell surface epitopes and RAP-1 molecular size were conserved in both B. bovis and B. bigemina.
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Details
- Title
- Interstrain conservation of babesial RAP-1 surface-exposed B-cell epitopes despite rap-1 genomic polymorphism
- Creators
- C E Suarez - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040T F McElwainI EchaideS Torioni de EchaideG H Palmer
- Publication Details
- Infection and immunity, Vol.62(8), pp.3576-3579
- Academic Unit
- Veterinary Microbiology and Pathology, Department of; Paul G. Allen School for Global Animal Health
- Publisher
- United States
- Identifiers
- 99900547210401842
- Language
- English
- Resource Type
- Journal article