Journal article
Intracerebroventricular ethanol-induced conditioned place preferences are prevented by fluphenazine infusions into the nucleus accumbens of rats
Behavioral neuroscience, Vol.121(2), pp.401-410
04/2007
Handle:
https://hdl.handle.net/2376/104075
PMID: 17469930
Abstract
The rewarding properties of centrally administered ethanol (EtOH) were examined using a conditioned place preference (CPP) test. Male rats subjected to bilateral intracerebroventricular (icv) infusions of EtOH (0-240 nmol) produced a dose-dependent preference for the drug-paired environment that was potentiated by concurrent intravenous (iv) administration of heroin (0.025 mg/kg). The role of mesolimbic dopamine (DA) pathways in the development of EtOH reward was then examined by challenging EtOH-treated rats with bilateral intra-accumbens shell applications of a DA receptor antagonist. Fluphenazine (10 or 50 microg/side), infused immediately prior to daily place conditioning trials, was found to reliably attenuate the development of CPPs produced by icv EtOH administration. When fluphenazine was administered into the nucleus accumbens shell prior to the final test trial only (i.e., in already conditioned rats), intra-accumbens shell DA receptor blockade was found to prevent the expression of CPPs produced by icv EtOH. In summary, rats form reliable learned preferences for EtOH-paired locations (CPPs) that are potentiated by iv heroin and whose acquisition and expression rely on intact DA functionality within the nucleus accumbens.
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Details
- Title
- Intracerebroventricular ethanol-induced conditioned place preferences are prevented by fluphenazine infusions into the nucleus accumbens of rats
- Creators
- Brendan M Walker - Behavioral Pharmacology Laboratory, Department of Psychology, University of California, Santa Barbara, CA 93106, USAAaron Ettenberg
- Publication Details
- Behavioral neuroscience, Vol.121(2), pp.401-410
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- United States
- Grant note
- F31 DA006019-01A1 / NIDA NIH HHS DA05041 / NIDA NIH HHS DA06019 / NIDA NIH HHS F31 DA006019-02 / NIDA NIH HHS F31 DA006019 / NIDA NIH HHS
- Identifiers
- 99900546998001842
- Language
- English
- Resource Type
- Journal article