Journal article
Intracerebroventricularly applied peptidase inhibitors increase endogenous angiotensin levels
Brain research, Vol.529(1), pp.126-130
1990
Handle:
https://hdl.handle.net/2376/113409
PMID: 2282487
Abstract
Rats received the aminopeptidase inhibitors amastatin (AM) and bestatin (BE), and carboxypeptidase inhibitor Plummer's (PL) via intracerebroventriclar infusion in various combinations, i.e. PL alone, AM + BE, and a cocktail consisting of AM + BE + PL. Blood pressure responses were recorded and a postinfusion sample of cerebrospinal fluid (CSF) was radioimmunoassayed for endogenous angiotensin levels. Results indicate that CSF angiotensin was increased approximately 1.5× over control levels when PL was infused; a 2.5× increase accompanied AM + BE administration; and a 10.3× elevation was measured when all 3 inhibitors were infused as a cocktail. Concomitant elevations in blood pressure accompanied increased concentrations of angiotensin. We conclude that endogenous levels of angiotensin can be significantly increased in the ventricular space when a combination of these inhibitors is utilized to protect both the amino and carboxyl terminals of the angiotensin molecule from enzymatic degradation.
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Details
- Title
- Intracerebroventricularly applied peptidase inhibitors increase endogenous angiotensin levels
- Creators
- Carol M Batt - Department of Psychology, Washington State University, Pullman, WA 99164-6520, U.S.ALaurie L Jensen - Department of Psychology, Washington State University, Pullman, WA 99164-6520, U.S.AJodie M Hanesworth - Departments of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164-6520, U.S.AJoseph W Harding - Department of Psychology, Washington State University, Pullman, WA 99164-6520, U.S.AJohn W Wright - Department of Psychology, Washington State University, Pullman, WA 99164-6520, U.S.A
- Publication Details
- Brain research, Vol.529(1), pp.126-130
- Academic Unit
- Psychology, Department of; Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900547958201842
- Language
- English
- Resource Type
- Journal article