Journal article
Intraperitoneal injection of cholecystokinin elicits sleep in rabbits
Physiology & behavior, Vol.50(6), pp.1241-1244
1991
Handle:
https://hdl.handle.net/2376/112583
PMID: 1798781
Abstract
Cholecystokinin (CCK) reduces food intake and promotes non-rapid-eye-movement sleep (NREMS) in rats. The purpose of present experiments was to determine if CCK is somnogenic in rabbits; another species in which CCK suppresses feeding. White New Zealand rabbits were treated intracerebroventricularly (ICV; 0.05, 0.5 and 2 μg) or intraperitoneally (IP; 2.5, 10 and 40 μg/kg) with CCK or saline, and sleep-wake activity and brain temperature (T
br) were recorded for 6 h. Injections of 10 and 40 μg/kg CCK IP elicited a decrease in wakefulness and an increase in NREMS during the first hour postinjection. The hypnogenic effects were accompanied by a decrease in T
br. After the IP injection of a lower dose (2.5 μg/kg) a slight, nonsignificant increase in NREMS during the first hour postinjection was followed by a decrease in NREMS. ICV injections of CCK had relatively small inhibitory effects on sleep. We conclude that circulating, hormone CCK might be a hypnogenic signal with a peripheral site of action.
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Details
- Title
- Intraperitoneal injection of cholecystokinin elicits sleep in rabbits
- Creators
- Levente Kapás - Department of Physiology and Biophysics, University of Tennessee, Memphis, TN USAFerenc Obál - Department of Physiology, Albert Szent-Györgyi Medical University, Szeged, HungaryMark R Opp - Department of Physiology and Biophysics, University of Tennessee, Memphis, TN USALars Johannsen - Department of Physiology and Biophysics, University of Tennessee, Memphis, TN USAJames M Krueger - Department of Physiology and Biophysics, University of Tennessee, Memphis, TN USA
- Publication Details
- Physiology & behavior, Vol.50(6), pp.1241-1244
- Academic Unit
- Biomedical Sciences, Department of; Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900547756501842
- Language
- English
- Resource Type
- Journal article