Journal article
Investigation of the effect of sex on hyperbaric oxygen (HBO2)-induced antinociception in a rat model of neuropathic pain
The journal of pain, Vol.17(4), pp.S53-S53
04/2016
Handle:
https://hdl.handle.net/2376/118726
Abstract
Hyperbaric oxygen (HBO2) therapy is an emerging treatment for neuropathic pain. HBO2 has been shown to decrease allodynia in animal models of neuropathic pain1 as well as human patients.2 Previously we reported that a single HBO2 treatment could suppress mechanical allodynia, while 4 treatments were needed to inhibit cold allodynia in the paclitaxel model in male rats.1 Women are more likely to develop neuropathic pain conditions than men.3 Preclinical investigations of the efficacy of HBO2 in treating pain have not investigated whether there are sex differences in HBO2-induced antinociception. The purpose of this experiment was to investigate whether sex affects HBO2 pain relief in the paclitaxel model of chronic pain. Male and female Sprague Dawley rats were treated with 1.0 mg/kg paclitaxel 4 times (4x) on alternate days prior to starting 4x daily 60-min HBO2 treatments at 3.5 atmospheres absolute. Then they were tested twice then once weekly for mechanical (von Frey) and cold allodynia (acetone) for 45 days. Results show that 4x HBO2 treatments reversed mechanical allodynia in both males and females for at least 45 days’ duration. However, 4x HBO2 suppressed cold allodynia only in male animals. The difference in cold allodynic response between the sexes was not statistically significant. Neither paclitaxel nor HBO2 affected percent weight gain or locomotor activity in either males or females. This study is the first to examine effects of HBO2 in male and female animals. This study extends previous results by including rats of both sexes in investigating the effects of HBO2. (1. Zhang et al., Soc Neurosci Abst, 2015; 2. Efrati et al., PLOS One, 2015; 3. Unruh, Pain, 1996.) This research was supported by the Marchionne Summer research fellowship from Washington State University and NIH Grant AT-007222.
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Details
- Title
- Investigation of the effect of sex on hyperbaric oxygen (HBO2)-induced antinociception in a rat model of neuropathic pain
- Creators
- A. Brewer - Washington State UniversityY. Zhang - Washington State UniversityD. Shirachi - Washington State UniversityR. Quock - Washington State UniversityR. Craft - Washington State University
- Publication Details
- The journal of pain, Vol.17(4), pp.S53-S53
- Academic Unit
- Psychology, Department of
- Identifiers
- 99900907796601842
- Language
- English
- Resource Type
- Journal article