Journal article
Involuntary Smoking and Head and Neck Cancer Risk: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
Cancer epidemiology, biomarkers & prevention, Vol.17(8), pp.1974-1981
08/2008
Handle:
https://hdl.handle.net/2376/105811
PMCID: PMC2561190
PMID: 18708387
Abstract
While active tobacco smoking has been identified as a major risk factor for head and neck cancer, involuntary smoking has not been adequately evaluated because of the relatively low statistical power in previous studies. We took advantage of data pooled in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium to evaluate the role of involuntary smoking in head and neck carcinogenesis. Involuntary smoking exposure data were pooled across six case-control studies in Central Europe, Latin America, and the U.S. Adjusted odds ratios (OR) and 95% confidence interval (95% CI) were estimated for 542 cases and 2197 controls who reported never using tobacco, and the heterogeneity among the study-specific ORs was assessed. In addition, stratified analyses were performed by subsite. No effect of ever involuntary smoking exposure either at home or at work was observed for head and neck cancer overall. However, long duration of involuntary smoking exposure at home and at work was associated with an increased risk (OR for >15 years at home: 1.60; 95%-CI 1.12, 2.28;
p
for trend <0.01; at work: 1.55; 95%-CI 1.04, 2.30;
p
for trend 0.13). The effect of duration of involuntary smoking exposure at home was stronger for pharyngeal and laryngeal cancers than for other subsites. An association between involuntary smoking exposure and the risk of head and neck cancer, particularly pharyngeal and laryngeal cancers, was observed for long duration of exposure. These results are consistent with those for active smoking and suggest that elimination of involuntary smoking exposure might reduce head and neck cancer risk among never smokers.
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Details
- Title
- Involuntary Smoking and Head and Neck Cancer Risk
- Creators
- Yuan-Chin Amy Lee - International Agency for Research on Cancer, Lyon, FrancePaolo Boffetta - International Agency for Research on Cancer, Lyon, FranceErich M Sturgis - UT-M.D. Anderson Cancer Center, Houston, Texas, USAQingyi Wei - UT-M.D. Anderson Cancer Center, Houston, Texas, USAZuo-Feng Zhang - UCLA School of Public Health, Los Angeles, CA, USAJoshua Muscat - Penn State College of Medicine, Hershey, PA, USAPhilip Lazarus - Penn State College of Medicine, Hershey, PA, USAElena Matos - Institute of Oncology Angel H. Roffo, University of Buenos Aires, ArgentinaRichard B Hayes - National Cancer Institute, Bethesda, MDDeborah M Winn - National Cancer Institute, Bethesda, MDDavid Zaridze - Cancer Research Centre, Moscow, RussiaVictor Wünsch-Filho - Universidade de Sao Paulo, São Paulo, BrazilJose Eluf-Neto - Universidade de Sao Paulo, São Paulo, BrazilSergio Koifman - Escola Nacional de Saude Publica, Fundacao Oswaldo Cruz, Rio de Janeiro, BrazilDana Mates - Institute of Public Health, Bucharest, RomaniaMaria Paula Curado - Hospital Araujo Jorge, Goiânia, BrazilAna Menezes - Universidade Federal de Pelotas, Pelotas, BrazilLeticia Fernandez - Institute of Oncology and Radiobiology, Havana, CubaAlexander W Daudt - Hospital de Clinicas de Porto Alegre, Porto Alegre, BrazilNeonila Szeszenia-Dabrowska - Institute of Occupational Medicine, Lodz, PolandEleonora Fabianova - Specialized State Health Institute, Banská Bystrica, SlovakiaPeter Rudnai - National Institute of Environmental Health, Budapest, HungaryGilles Ferro - International Agency for Research on Cancer, Lyon, FranceJulien Berthiller - International Agency for Research on Cancer, Lyon, FrancePaul Brennan - International Agency for Research on Cancer, Lyon, FranceMia Hashibe - International Agency for Research on Cancer, Lyon, France
- Publication Details
- Cancer epidemiology, biomarkers & prevention, Vol.17(8), pp.1974-1981
- Academic Unit
- Pharmaceutical Sciences, Department of
- Identifiers
- 99900546877301842
- Language
- English
- Resource Type
- Journal article