Journal article
Involvement of cyclic GMP-dependent protein kinase in nitrous oxide-induced anxiolytic-like behavior in the mouse light/dark exploration test
Brain research, Vol.1038(1), pp.113-117
2005
Handle:
https://hdl.handle.net/2376/115874
PMID: 15748880
Abstract
The second messenger cyclic GMP (cGMP) plays a role in the anxiolytic-like behavioral response of mice to nitrous oxide (N
2O). This study was conducted to determine whether this behavioral effect of N
2O is affected by inhibition of cGMP-dependent protein kinase (PKG). N
2O-induced behavior in the light/dark exploration test was significantly attenuated by the PKG inhibitors H-8 and Rp-8-pCPT-cGMPS but not Rp-8-pCPT-cAMPS, an inhibitor of cAMP-dependent protein kinase. These findings implicate PKG in the mediation or modulation of the anxiolytic-like behavioral response to N
2O.
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Details
- Title
- Involvement of cyclic GMP-dependent protein kinase in nitrous oxide-induced anxiolytic-like behavior in the mouse light/dark exploration test
- Creators
- Shuang Li - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, WA 99164-6534, USAJason C Doss - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, WA 99164-6534, USAElizabeth J Hardee - Graduate Program in Pharmacology and Toxicology, Washington State University, Pullman, WA 99164-6534, USARaymond M Quock - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, WA 99164-6534, USA
- Publication Details
- Brain research, Vol.1038(1), pp.113-117
- Academic Unit
- Psychology, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900547657401842
- Language
- English
- Resource Type
- Journal article