Journal article
Involvement of prolactin in the REM sleep-promoting activity of systemic vasoactive intestinal peptide (VIP)
Brain research, Vol.645(1), pp.143-149
1994
Handle:
https://hdl.handle.net/2376/107093
PMID: 8062077
Abstract
The involvement of pituitary prolactin (PRL) in systemic vasoactive intestinal peptide (VIP)-induced sleep was studied. Male rats were implanted with electrodes for EEG-recording, with brain thermistors to record cortical temperature (
T
crt) and with chronic intracardial catheters to obtain blood samples and to deliver substances. One group of rats (
n = 8) received normal rabbit serum (NS) + physiological saline (SAL) on the baseline day and was injected with NS + VIP on the experimental day. In the other group of rats (
n = 6), the baseline day was followed by administration of PRL-antiserum (PRL-AS) + VIP on the experimental day. The sera and VIP or SAL were injected 30 min before and at light onset, respectively. Sleep-wake activity was then recorded for the next 12-h light period. Systemic VIP-stimulated PRL secretion as measured by RIA in serial samples obtained hour 1 postinjection. VIP also elicited selective increases in REM sleep (REMS) in the rats pretreated with NS.
T
crt was not affected by VIP. Administration of PRL-AS blocked the increase in circulating levels of free (non-IgG-bound) PRL and prevented VIP-enhanced REMS. Comparisons of the sleep effects of PRL-AS + VIP with the previously reported changes in sleep after PRL-AS alone indicate that PRL has a major role in the mediation of the REMS-promoting activity of systemic VIP. The results suggest that an increased release of endogenous pituitary PRL modulates REMS.
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Details
- Title
- Involvement of prolactin in the REM sleep-promoting activity of systemic vasoactive intestinal peptide (VIP)
- Creators
- F Obál - Department of Physiology, Albert Szent-Györgyi Medical University, Szeged, HungaryL Payne - Department of Physiology and Biophysics, University of Alabama, Birmingham, AL, USAB Kacsoh - Division of Basic Medical Sciences, Mercer University School of Medicine, Macon, GA, USAM Opp - Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, TX, USAL Kapás - Department of Physiology and Biophysics, University of Tennessee, 894 Union Avenue, Memphis, TN 38163, USAC.E Grosvenor - Department of Molecular and Cell Biology, Pennsylvania State University, University Park, PA, USAJ.M Krueger - Department of Physiology and Biophysics, University of Tennessee, 894 Union Avenue, Memphis, TN 38163, USA
- Publication Details
- Brain research, Vol.645(1), pp.143-149
- Academic Unit
- Biomedical Sciences, Department of; Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900546981901842
- Language
- English
- Resource Type
- Journal article