Iron-Imprinted Single-Atomic Site Catalyst-Based Nanoprobe for Detection of Hydrogen Peroxide in Living Cells

Zhaoyuan Lyu; Shichao Ding; Maoyu Wang; Xiaoqing Pan; Zhenxing Feng; Hangyu Tian; Chengzhou Zhu; Dan Du; Yuehe Lin

doi:10.1007/s40820-021-00661-z

Back

Iron-Imprinted Single-Atomic Site Catalyst-Based Nanoprobe for Detection of Hydrogen Peroxide in Living Cells

Journal article

Open access

Peer reviewed

Iron-Imprinted Single-Atomic Site Catalyst-Based Nanoprobe for Detection of Hydrogen Peroxide in Living Cells

Zhaoyuan Lyu, Shichao Ding, Maoyu Wang, Xiaoqing Pan, Zhenxing Feng, Hangyu Tian, Chengzhou Zhu, Dan Du and Yuehe Lin

Nano-micro letters, Vol.13(1), 146

12/01/2021

DOI: https://doi.org/10.1007/s40820-021-00661-z

PMID: 34146178

Files and links (2)

pdf

s40820-021-00661-z2.36 MBDownload View

CC BY V4.0, Open Access

url

https://doi.org/10.1007/s40820-021-00661-zView

Published (Version of record) Open

Abstract

Materials Science, Multidisciplinary

Nanoscience & Nanotechnology

Physics, Applied

Materials Science

Physical Sciences

Physics

Fe-based single-atomic site catalysts (SASCs), with the natural metalloproteases-like active site structure, have attracted widespread attention in biocatalysis and biosensing. Precisely, controlling the isolated single-atom Fe-N-C active site structure is crucial to improve the SASCs' performance. In this work, we use a facile ion-imprinting method (IIM) to synthesize isolated Fe-N-C single-atomic site catalysts (IIM-Fe-SASC). With this method, the ion-imprinting process can precisely control ion at the atomic level and form numerous well-defined single-atomic Fe-N-C sites. The IIM-Fe-SASC shows better peroxidase-like activities than that of non-imprinted references. Due to its excellent properties, IIM-Fe-SASC is an ideal nanoprobe used in the colorimetric biosensing of hydrogen peroxide (H2O2). Using IIM-Fe-SASC as the nanoprobe, in situ detection of H2O2 generated from MDA-MB-231 cells has been successfully demonstrated with satisfactory sensitivity and specificity. This work opens a novel and easy route in designing advanced SASC and provides a sensitive tool for intracellular H2O2 detection.

Metrics

1 Record Views

See more details

Details

Title: Iron-Imprinted Single-Atomic Site Catalyst-Based Nanoprobe for Detection of Hydrogen Peroxide in Living Cells
Creators: Zhaoyuan Lyu - Washington State University
Shichao Ding - Washington State University
Maoyu Wang - Oregon State University
Xiaoqing Pan - University of California, Irvine
Zhenxing Feng - Oregon State University
Hangyu Tian - Washington State University
Chengzhou Zhu - Washington State University
Dan Du - Washington State University
Yuehe Lin - Washington State University
Publication Details: Nano-micro letters, Vol.13(1), 146
Academic Unit: School of Mechanical and Materials Engineering
Publisher: Shanghai Jiao Tong Univ Press
Number of pages: 13
Grant note: DE-AC02-06CH11357 / U.S. Department of Energy; United States Department of Energy (DOE) WSU startup fund
Identifiers: 99901227840901842
Language: English
Resource Type: Journal article