Journal article
Iron mediates Trichomonas vaginalis resistance to complement lysis
Microbial pathogenesis, Vol.19(2), pp.93-103
1995
Handle:
https://hdl.handle.net/2376/114717
PMID: 8577239
Abstract
Trichomonas vaginalis, a sexually transmitted disease agent in humans, is readily lysed by activation of the alternative complement pathway. The parasite became resistant following growth in medium supplemented by iron compared to parasites grown in medium depleted of iron, which were readily killed by complement. The resistance to complement was dependent on iron concentration while divalent cations other than iron were ineffective, showing specific regulation of this property by iron. Lactoferrin, but not transferrin, rendered low-iron-parasites resistant to complement lysis, reinforcing the
in vivomodulation by a known source of iron for this parasite. Pretreatment of high-iron, complement-resistant parasites with proteinase inhibitors resulted in lysis by complement, indicating that resistance was likely due to proteinase degradation of C3 on the trichomonal surface.
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Details
- Title
- Iron mediates Trichomonas vaginalis resistance to complement lysis
- Creators
- John F Alderete - Department of Microbiology, The University of Texas Health Science Center, San Antonio, TX, 78284–7758Daniele Provenzano - Department of Microbiology, The University of Texas Health Science Center, San Antonio, TX, 78284–7758Michael W Lehker - Department of Biological Sciences and Border Biomedical Research Center, University of Texas, El Paso, TX, 79968–0519, U.S.A
- Publication Details
- Microbial pathogenesis, Vol.19(2), pp.93-103
- Academic Unit
- Molecular Biosciences, School of
- Publisher
- Elsevier India Pvt Ltd
- Identifiers
- 99900547620101842
- Language
- English
- Resource Type
- Journal article