Journal article
L-364,718, a cholecystokinin-A receptor antagonist, suppresses feeding-induced sleep in rats
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.280(5), pp.R1420-R1426
05/01/2001
Handle:
https://hdl.handle.net/2376/113950
PMID: 11294763
Abstract
Feeding induces increased sleep in several species, including rats. The aim of the study was to determine if CCK plays a role in sleep responses to feeding. We induced excess eating in rats by 4 days of starvation and studied the sleep responses to refeeding in control and CCK-A receptor antagonist-treated animals. Sleep was recorded on 2 baseline days when food was provided ad libitum. After the starvation period, sleep was recorded on 2 refeeding days when the control rats ( n = 8) were injected with vehicle and the experimental animals ( n = 8) received intraperitoneal injections of L-364,718 (500 μg/kg, on both refeeding days). In the control group, refeeding caused increases in rapid eye movement sleep (REMS) and non-REMS (NREMS) and decreases in NREMS intensity as indicated by the slow-wave activity (SWA) of the electroencephalogram. CCK-A receptor antagonist treatment completely prevented the SWA responses and delayed the NREMS responses to refeeding; REMS responses were not simply abolished, but the amount of REMS was below baseline after the antagonist treatment. These results suggest that endogenous CCK, acting on CCK-A receptors, may play a key role in eliciting postprandial sleep.
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Details
- Title
- L-364,718, a cholecystokinin-A receptor antagonist, suppresses feeding-induced sleep in rats
- Creators
- Alexei Shemyakin - Department of Biological Sciences, Fordham University, Bronx, New York 10458Levente Kapás - Department of Biological Sciences, Fordham University, Bronx, New York 10458
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.280(5), pp.R1420-R1426
- Academic Unit
- Biomedical Sciences, Department of
- Identifiers
- 99900547998101842
- Language
- English
- Resource Type
- Journal article