Journal article
Leptin Is Present in Human Milk and Is Related to Maternal Plasma Leptin Concentration and Adiposity
Biochemical and biophysical research communications, Vol.240(3), pp.742-747
11/26/1997
Handle:
https://hdl.handle.net/2376/116023
PMID: 9398637
Abstract
Leptin is elevated during pregnancy and may be involved in the regulation of milk production in women. Immunoreactive leptin was quantified in human milk by modified radioimmunoassay. Leptin concentration was higher in whole vs. skim milk fractions; however, leptin concentration was not correlated with percentage milk fat. Leptin concentrations in whole and skim milk were correlated with maternal plasma leptin concentrations, maternal body weight, body mass index, and tricep skinfold thickness, but not with plasma insulin concentration. These data provide the first evidence for the presence of leptin in human milk in the range of concentrations found in human plasma and indicate that the concentration of leptin in milk reflects maternal adiposity. Determining the biological role(s) of milk-borne leptin could add to our understanding of neonatal metabolism and the mechanisms underlying the development of body fat and obesity in humans.
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Details
- Title
- Leptin Is Present in Human Milk and Is Related to Maternal Plasma Leptin Concentration and Adiposity
- Creators
- Karen L Houseknecht - Department of Animal Sciences, Purdue University, West Lafayette, Indiana, 47907Michelle K McGuire - Animal and Veterinary Science Department, University of Idaho, Moscow, Idaho, 83843Carla P Portocarrero - Department of Animal Sciences, Purdue University, West Lafayette, Indiana, 47907Mark A McGuire - Animal and Veterinary Science Department, University of Idaho, Moscow, Idaho, 83843Kathy Beerman - Department of Food Science and Human Nutrition, Washington State University, Pullman, Washington, 99164
- Publication Details
- Biochemical and biophysical research communications, Vol.240(3), pp.742-747
- Academic Unit
- Paul G. Allen School for Global Animal Health; Biological Sciences, School of
- Publisher
- Elsevier Inc
- Identifiers
- 99900547627801842
- Language
- English
- Resource Type
- Journal article