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Less means more: inhibition of spontaneous firing triggers persistent increases in excitability
Journal article   Open access  Peer reviewed

Less means more: inhibition of spontaneous firing triggers persistent increases in excitability

Michael Häusser and Pablo Monsivais
Neuron (Cambridge, Mass.), Vol.40(3), pp.449-451
10/30/2003
DOI: https://doi.org/10.1016/S0896-6273(03)00686-X
Handle:
https://hdl.handle.net/2376/104030
PMID: 14642267
url
https://doi.org/10.1016/S0896-6273(03)00686-XView
Published (Version of record) Open

Abstract

Large-Conductance Calcium-Activated Potassium Channels Neural Inhibition - physiology Potassium Channels, Calcium-Activated - physiology Animals Neuronal Plasticity - physiology Calcium - metabolism Synapses - physiology Neurons - physiology Mice In Vitro Techniques Nerve Net - physiology
Modulation of intrinsic excitability is an alternative to classical synaptic plasticity for implementing activity-dependent changes in neuronal networks. In this issue of Neuron, Nelson et al. reveal a new form of plasticity of intrinsic excitability that can be triggered rapidly when synaptic inhibition reduces spontaneous firing, resulting in persistent enhancement of firing rate and neuronal gain.

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