Like pigs, and unlike other breeds of cattle examined, mature Angus-derived adipocytes may extrude lipid prior to proliferation in vitro

Shengjuan Wei; Marcio S Duarte; Min Du; Zhihua Jiang; Pedro V.R Paulino; Jie Chen; Melinda Fernyhough-Culver; Gary J Hausman; Linsen Zan; Michael V Dodson

doi:10.4161/adip.21447

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Like pigs, and unlike other breeds of cattle examined, mature Angus-derived adipocytes may extrude lipid prior to proliferation in vitro

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Like pigs, and unlike other breeds of cattle examined, mature Angus-derived adipocytes may extrude lipid prior to proliferation in vitro

Shengjuan Wei, Marcio S Duarte, Min Du, Zhihua Jiang, Pedro V.R Paulino, Jie Chen, Melinda Fernyhough-Culver, Gary J Hausman, Linsen Zan and Michael V Dodson

Adipocyte, Vol.1(4), pp.237-241

10/01/2012

DOI: https://doi.org/10.4161/adip.21447

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https://hdl.handle.net/2376/105539

PMCID: PMC3609105

PMID: 23700538

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Abstract

Brief Report

dedifferentiation

lipids

cattle

proliferation

mature adipocytes

A large number of studies have shown that mature adipocytes are able to dedifferentiate in vitro into progeny cells, which possess proliferative capacity and mutilineage potential. Our present study confirms that mature adipocytes derived from Angus cattle also dedifferentiate into proliferative-competent progeny cells. However, this report is unlike any published for all other breeds of cattle we have worked with or that we have seen in published reports, in which mature adipocytes retain and distribute lipids into daughter cells symmetrically or asymmetrically. In the present work, we noted that Angus-derived mature adipocytes extruded a majority of their cellular lipid droplets prior to cell division. In this manner, these cells are processing lipid in a manner observed in mature adipocytes isolated from swine tissue. These results suggest that regulation of the mechanism(s) underlying lipid processing might be different between and within animal breeds. Lipid processing in beef-derived adipocytes during dedifferentiation may serve as a unique animal model for studying lipid metabolism during reverse adipogenesis.

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Title: Like pigs, and unlike other breeds of cattle examined, mature Angus-derived adipocytes may extrude lipid prior to proliferation in vitro
Creators: Shengjuan Wei - College of Animal Science and Technology; Northwest A&F University; Yangling, China
Marcio S Duarte - Department of Animal Sciences; Washington State University; Pullman, WA USA
Min Du - Department of Animal Sciences; Washington State University; Pullman, WA USA
Zhihua Jiang - Department of Animal Sciences; Washington State University; Pullman, WA USA
Pedro V.R Paulino - Department of Animal Sciences; Universidade Federal de Viçosa; Viçosa, Brazil
Jie Chen - College of Animal Science and Technology; Nanjing Agricultural University; Nanjing, China
Melinda Fernyhough-Culver - The Hartz Mountain Corporation; Secaucus, NJ USA
Gary J Hausman - USDA-ARS; Richard B. Russell Agricultural Research Station; Athens, GA USA
Linsen Zan - College of Animal Science and Technology; Northwest A&F University; Yangling, China
Michael V Dodson - Department of Animal Sciences; Washington State University; Pullman, WA USA
Publication Details: Adipocyte, Vol.1(4), pp.237-241
Academic Unit: Animal Sciences, Department of
Publisher: Landes Bioscience
Identifiers: 99900547000901842
Language: English
Resource Type: Journal article