Journal article
Links between the innate immune system and sleep
Journal of allergy and clinical immunology, Vol.116(6), pp.1188-1198
12/2005
Handle:
https://hdl.handle.net/2376/105582
PMID: 16337444
Abstract
Sleep is a fundamental physiologic process with unknown functions. It is divided into 2 distinct states: non-rapid-eye-movement sleep and rapid-eye-movement sleep. After acute infection with nonneurotropic agents, there are stereotypic changes in non-rapid-eye-movement sleep, particularly increased time spent in slow-wave sleep, and often a reduction of time spent in rapid-eye-movement sleep. It is now recognized that both infection-associated sleep and spontaneous sleep are regulated, in part, by immune mediators called cytokines. This review provides brief tutorials on the elements of the innate immune system that detect infection, how sleep is characterized in the laboratory, issues regarding the interpretation of sleep effects on immune function, the interaction of sleep with circadian rhythms and stress, and some of the microbial products, cytokines, and neuropeptides associated with sleep regulation. We also summarize our current understanding of the role of sleep in host defense and asthma exacerbation.
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Details
- Title
- Links between the innate immune system and sleep
- Creators
- Jeannine A Majde - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164-6520, USAJames M Krueger
- Publication Details
- Journal of allergy and clinical immunology, Vol.116(6), pp.1188-1198
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- United States
- Grant note
- NS31453 / NINDS NIH HHS HD36520 / NICHD NIH HHS NS25378 / NINDS NIH HHS
- Identifiers
- 99900546900201842
- Language
- English
- Resource Type
- Journal article