Journal article
Lipoproteins, cholesterol homeostasis and cardiac health
International journal of biological sciences, Vol.5(5), pp.474-488
01/01/2009
Handle:
https://hdl.handle.net/2376/112618
PMCID: PMC2706428
PMID: 19584955
Abstract
Cholesterol is an essential substance involved in many functions, such as maintaining cell membranes, manufacturing vitamin D on surface of the skin, producing hormones, and possibly helping cell connections in the brain. When cholesterol levels rise in the blood, they can, however, have dangerous consequences. In particular, cholesterol has generated considerable notoriety for its causative role in atherosclerosis, the leading cause of death in developed countries around the world. Homeostasis of cholesterol is centered on the metabolism of lipoproteins, which mediate transport of the lipid to and from tissues. As a synopsis of the major events and proteins that manage lipoprotein homeostasis, this review contributes to the substantial attention that has recently been directed to this area. Despite intense scrutiny, the majority of phenotypic variation in total cholesterol and related traits eludes explanation by current genetic knowledge. This is somewhat disappointing considering heritability estimates have established these traits as highly genetic. Thus, the continued search for candidate genes, mutations, and mechanisms is vital to our understanding of heart disease at the molecular level. Furthermore, as marker development continues to predict risk of vascular illness, this knowledge has the potential to revolutionize treatment of this leading human disease.
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Details
- Title
- Lipoproteins, cholesterol homeostasis and cardiac health
- Creators
- Tyler F Daniels - 1. Department of Animal Sciences, Washington State University, Pullman, WA 99164-6351, USAKaren M Killinger - 2. School of Food Science, Washington State University, Pullman, WA 99164-6376, USAJennifer J Michal - 1. Department of Animal Sciences, Washington State University, Pullman, WA 99164-6351, USARaymond W Wright Jr - 1. Department of Animal Sciences, Washington State University, Pullman, WA 99164-6351, USAZhihua Jiang - 1. Department of Animal Sciences, Washington State University, Pullman, WA 99164-6351, USA
- Publication Details
- International journal of biological sciences, Vol.5(5), pp.474-488
- Academic Unit
- Animal Sciences, Department of
- Publisher
- Ivyspring International Publisher; Sydney
- Identifiers
- 99900548248301842
- Language
- English
- Resource Type
- Journal article